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Tclin
ANGPTL3
Angiopoietin-related protein 3

Protein Summary
Description
Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed:17110602, PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371129
  • ENSP00000360170
  • ENSG00000132855

Symbol
  • ANGPT5
  • ANL3
  • ANG-5
  • FHBL2
  • ANGPT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.84
biological process
0.79
gene perturbation
0.76
biological term
0.56
tissue
0.51


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.97   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.97   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
CCDC91
Tbio
Novelty:  0.11171935
p_int:  0.999900211
p_ni:  0.000087844
p_wrong:  0.000011946
Score:  0.332
Data Source:  BioPlex,STRINGDB
GULP1
Tbio
Novelty:  0.01367525
p_int:  0.999545931
p_ni:  0.000454017
p_wrong:  5.2e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999417986
p_ni:  0.000582014
Score:  0.179
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.993239067
p_ni:  0.006760933
Score:  0.188
Data Source:  BioPlex,STRINGDB
ANGPTL8
Tbio
Novelty:  0.00622889
Score:  0.994
Data Source:  Reactome,STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.981
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.966
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.942
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.938
Data Source:  STRINGDB
ANGPTL4
Tbio
Novelty:  0.00237867
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
12
15
28
2.9
99.6
triglyceride measurement
19
18
48
6
99.4
low density lipoprotein cholesterol measurement
8
12
20
2
99
sleep duration
2
2
2
92.6
vitamin D measurement
2
2
2
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
28
2.9
99.6
triglyceride measurement
48
6
99.4
low density lipoprotein cholesterol measurement
20
2
99
sleep duration
2
92.6
vitamin D measurement
2
89.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiopoietin like 3
VGNC:86
742370
Mouse
MGI:1353627
30924
Rat
RGD:1564505
502970
Dog
angiopoietin like 3
VGNC:37859
102152922
Horse
angiopoietin like 3
VGNC:15302
100054159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiopoietin like 3
Mouse
Rat
Dog
angiopoietin like 3
Horse
angiopoietin like 3
Publication Statistics
PubMed Score 235.97
PubMed score by year
PubTator Score 124.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title