Tbio SUPT16H FACT complex subunit SPT16

Protein Summary

Description

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9Y5B9
• Q6GMT8
• Q6P2F1
• Q6PJM1
• Q9NRX0

Gene Name

• SUPT16H

Ensembl ID

• ENST00000216297
• ENSP00000216297
• ENSG00000092201

Symbol

• FACT140
• FACTP140
• CDC68
• SPT16
• FACTP140
• SPT16/CDC68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.94
transcription factor perturbation	0.84
histone modification site profile	0.83
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Fact Complex Subunit Spt16

Protein / Nucleic Acid Binding / Fact Complex Subunit Spt16

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Fact Complex Subunit Spt16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.7   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 388   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.7   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0