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Tbio
NME7
Nucleoside diphosphate kinase 7

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367811
  • ENSP00000356785
  • ENSG00000143156
  • ENST00000472647
  • ENSP00000433341

Symbol
  • NDK7
  • NDK 7
  • CFAP67
  • MN23H7
  • nm23-H7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.89
biological process
0.87
transcription factor perturbation
0.8
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
p_int:  0.999907066
p_ni:  0.000092922
p_wrong:  1.1e-8
Score:  0.308
Data Source:  BioPlex,STRINGDB
TXNDC12
Tbio
Novelty:  0.01354011
p_int:  0.996372585
p_ni:  0.003627415
p_wrong:  1e-9
Score:  0.676
Data Source:  BioPlex,STRINGDB
MZT2B
Tdark
Novelty:  0.69469786
p_int:  0.996266779
p_ni:  0.003733221
Score:  0.991
Data Source:  BioPlex,STRINGDB
MZT1
Tdark
Novelty:  0.06713659
p_int:  0.994880374
p_ni:  0.005118762
p_wrong:  8.64e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
TUBG2
Tbio
Novelty:  0.14828466
p_int:  0.994137613
p_ni:  0.005862387
Score:  0.956
Data Source:  BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
p_int:  0.993666045
p_ni:  0.006333955
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.987749569
p_ni:  0.012250352
p_wrong:  7.9e-8
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.970044038
p_ni:  0.029955937
p_wrong:  2.4e-8
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.95776766
p_ni:  0.04223234
Data Source:  BioPlex
CSPP1
Tbio
Novelty:  0.02734691
p_int:  0.928992157
p_ni:  0.071007828
p_wrong:  1.5e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY1A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (30)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
3
2
98.5
electrocardiography
1
4
56
92.7
QT interval
6
10
3
2.2
91.3
3
2
3
69.1
intraocular pressure measurement
2
2
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
98.5
electrocardiography
56
92.7
QT interval
3
2.2
91.3
3
69.1
intraocular pressure measurement
2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 7
VGNC:11564
457498
Macaque
NME/NM23 family member 7
704372
Mouse
MGI:2449121
171567
Rat
RGD:619880
171566
Dog
NME/NM23 family member 7
VGNC:43858
100686107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 7
Macaque
NME/NM23 family member 7
Mouse
Rat
Dog
NME/NM23 family member 7
Publication Statistics
PubMed Score 13.71
PubMed score by year
PubTator Score 5.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title