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Tbio
PAXBP1
PAX3- and PAX7-binding protein 1

Protein Summary
Description
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290178
  • ENSP00000290178
  • ENSG00000159086
  • ENST00000331923
  • ENSP00000328992
  • ENST00000443785
  • ENSP00000393038
  • ENST00000573680
  • ENSP00000458892
  • ENSG00000263141
  • ENST00000574159
  • ENSP00000458262

Symbol
  • C21orf66
  • GCFC
  • GCFC1
  • GCFC
  • BM020
  • GCFC1
  • FSAP105
  • C21orf66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
molecular function
0.81
microRNA
0.8
biological process
0.79
histone modification site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
31.4
age at onset
1
1
0
5.9
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
31.4
age at onset
0
5.9
31.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAX3 and PAX7 binding protein 1
VGNC:1131
458510
Mouse
MGI:1914617
67367
Rat
RGD:1584739
681004
Dog
PAX3 and PAX7 binding protein 1
VGNC:44281
609740
Horse
PAX3 and PAX7 binding protein 1
VGNC:21179
100063627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAX3 and PAX7 binding protein 1
Mouse
Rat
Dog
PAX3 and PAX7 binding protein 1
Horse
PAX3 and PAX7 binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5B6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
RSRC1
Tbio
Novelty:  0.12148079
p_int:  0.999999541
p_ni:  3.69e-7
p_wrong:  8.9e-8
Score:  0.864
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999516
p_ni:  4.84e-7
Data Source:  BioPlex
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
p_int:  0.999998242
p_ni:  0.000001758
Score:  0.228
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999977239
p_ni:  0.000022761
Score:  0.157
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999956125
p_ni:  0.000043875
Score:  0.603
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.999831471
p_ni:  0.000168529
Score:  0.801
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999802048
p_ni:  0.000197952
Score:  0.399
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999480664
p_ni:  0.000518962
p_wrong:  3.74e-7
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999335959
p_ni:  0.000664041
Score:  0.325
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.99859962
p_ni:  0.00140038
Score:  0.561
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.85

PubMed score by year
PubTator Score  3.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer