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Tbio
PAXBP1
PAX3- and PAX7-binding protein 1

Protein Summary
Description
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290178
  • ENSP00000290178
  • ENSG00000159086
  • ENST00000331923
  • ENSP00000328992
  • ENST00000443785
  • ENSP00000393038
  • ENST00000573680
  • ENSP00000458892
  • ENSG00000263141
  • ENST00000574159
  • ENSP00000458262

Symbol
  • C21orf66
  • GCFC
  • GCFC1
  • GCFC
  • BM020
  • GCFC1
  • FSAP105
  • C21orf66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
molecular function
0.81
microRNA
0.8
biological process
0.79
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0