Tbio PAXBP1 PAX3- and PAX7-binding protein 1

Protein Summary

Description

Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q9Y5B6
• D3DSE7
• Q96DU8
• Q9NYQ0

Gene Name

• PAXBP1

Ensembl ID

• ENST00000290178
• ENSP00000290178
• ENSG00000159086
• ENST00000331923
• ENSP00000328992
• ENST00000443785
• ENSP00000393038
• ENST00000573680
• ENSP00000458892
• ENSG00000263141
• ENST00000574159
• ENSP00000458262

Symbol

• C21orf66
• GCFC
• GCFC1
• GCFC
• BM020
• GCFC1
• FSAP105
• C21orf66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
molecular function	0.81
microRNA	0.8
biological process	0.79
histone modification site profile	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Pax3- And Pax7-binding Protein 1

Protein / Nucleic Acid Binding / Pax3- And Pax7-binding Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Pax3- And Pax7-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0