Tbio CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase

Protein Summary

Description

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9Y5B0
• A8MY97
• Q7Z644
• Q96BZ1
• Q9Y6F5

Gene Name

• CTDP1

Ensembl ID

• ENST00000075430
• ENSP00000075430
• ENSG00000060069
• ENST00000613122
• ENSP00000484525

Symbol

• FCP1
• FCP1
• CCFDN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
histone modification site profile	0.84
pathway	0.78
small molecule perturbation	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Rna Polymerase Ii Subunit A C-terminal Domain Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Rna Polymerase Ii Subunit A C-terminal Domain Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.49   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.49   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0