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Tbio
YTHDF2
YTH domain-containing family protein 2

Protein Summary
Description
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373812
  • ENSP00000362918
  • ENSG00000198492
  • ENST00000541996
  • ENSP00000439394
  • ENST00000542507
  • ENSP00000444660

Symbol
  • HGRG8
  • CAHL
  • HGRG8
  • NY-REN-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
disease perturbation
0.97
virus perturbation
0.88
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.09   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.09   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
85
platelet count
2
2
2
53.1
basophil count
2
2
2
50.6
2
2
2
49.1
IGF-1 measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
85
platelet count
2
53.1
basophil count
2
50.6
2
49.1
IGF-1 measurement
1
42.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YTH N6-methyladenosine RNA binding protein 2
VGNC:10072
740305
Macaque
YTH N6-methyladenosine RNA binding protein 2
717225
Mouse
MGI:2444233
213541
Rat
RGD:1311321
313053
Dog
YTH N6-methyladenosine RNA binding protein 2
VGNC:48506
478161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YTH N6-methyladenosine RNA binding protein 2
Macaque
YTH N6-methyladenosine RNA binding protein 2
Mouse
Rat
Dog
YTH N6-methyladenosine RNA binding protein 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
ALKBH5
Tbio
Family:  Enzyme
Novelty:  0.01158189
Score:  0.914
Data Source:  STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
Score:  0.865
Data Source:  STRINGDB
USP5
Tchem
Family:  Enzyme
Novelty:  0.01478795
Score:  0.863
Data Source:  STRINGDB
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.854
Data Source:  STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
Score:  0.842
Data Source:  STRINGDB
AGL
Tbio
Novelty:  0.00166875
Score:  0.812
Data Source:  STRINGDB
WTAP
Tbio
Novelty:  0.01491546
Score:  0.798
Data Source:  STRINGDB
FTO
Tchem
Family:  Enzyme
Novelty:  0.00053473
Score:  0.704
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.704
Data Source:  STRINGDB
ALKBH1
Tbio
Family:  Enzyme
Novelty:  0.00504781
Score:  0.691
Data Source:  STRINGDB
Publication Statistics
PubMed Score  93.09

PubMed score by year
PubTator Score  19.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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