Tbio CEP83 Centrosomal protein of 83 kDa

Protein Summary

Description

Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q9Y592
• A4FVB1
• Q08AP1
• Cep83

Gene Name

• CEP83

Ensembl ID

• ENST00000339839
• ENSP00000344655
• ENSG00000173588
• ENST00000397809
• ENSP00000380911

Symbol

• CCDC41
• CCDC41
• NPHP18
• NY-REN-58

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
tissue sample	0.62
transcription factor binding site profile	0.62
transcription factor	0.61
cell line	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0