Tbio AP4S1 AP-4 complex subunit sigma-1

Protein Summary

Description

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9Y587
• G3V2N8
• Q6IAQ4
• Q86U36
• Q9BVE7

Gene Name

• AP4S1

Ensembl ID

• ENST00000216366
• ENSP00000216366
• ENSG00000100478
• ENST00000313566
• ENSP00000322508
• ENST00000334725
• ENSP00000334484
• ENST00000542754
• ENSP00000438170
• ENST00000554345
• ENSP00000450768
• ENST00000616371
• ENSP00000477631
• ENST00000622409
• ENSP00000482876

Symbol

• AP47B
• CLA20
• CPSQ6
• SPG52
• CLAPS4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
disease perturbation	0.79
transcription factor binding site profile	0.68
cell type or tissue	0.6
histone modification site profile	0.6

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Ap-4 Complex Subunit Sigma-1

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Ap-4 Complex Subunit Sigma-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0