AP4S1
AP-4 complex subunit sigma-1
Protein Summary
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein c ...more
- ENST00000216366
- ENSP00000216366
- ENSG00000100478
- ENST00000313566
- ENSP00000322508
- ENST00000334725
- ENSP00000334484
- ENST00000542754
- ENSP00000438170
- ENST00000554345
- ENSP00000450768
- ENST00000616371
- ENSP00000477631
- ENST00000622409
- ENSP00000482876
- AP47B
- CLA20
- CPSQ6
- SPG52
- CLAPS4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.68 | ||
cell type or tissue | 0.6 | ||
histone modification site profile | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.25 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 28 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.25 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 28 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (80)
AP4B1
Novelty: 0.08255831
p_int: 0.999999972
p_ni: 2.2e-8
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
TEPSIN
Novelty: 0.48775142
p_int: 0.99999233
p_ni: 4.1e-8
p_wrong: 0.000007628
Score: 0.713
Data Source: BioPlex,STRINGDB
DISC1
Novelty: 0.00183442
p_int: 0.997599366
p_ni: 4.42e-7
p_wrong: 0.002400193
Data Source: BioPlex
SUV39H2
Family: Epigenetic
Novelty: 0.02232167
p_int: 0.879595442
p_ni: 1.7e-8
p_wrong: 0.120404541
Score: 0.622
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Lysosome Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Reactome | trans-Golgi Network Vesicle Budding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Lysosome Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
trans-Golgi Network Vesicle Budding | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adaptor related protein complex 4 subunit sigma 1 | VGNC:7431 | 467417 | |||||
Macaque | adaptor related protein complex 4 sigma 1 subunit | 717146 | ||||||
Mouse | MGI:1337065 | 11782 | ||||||
Rat | RGD:1311990 | 366618 | ||||||
Horse | adaptor related protein complex 4 subunit sigma 1 | VGNC:15391 | 100050137 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adaptor related protein complex 4 subunit sigma 1 | |||||
Macaque | adaptor related protein complex 4 sigma 1 subunit | |||||
Mouse | ||||||
Rat | ||||||
Horse | adaptor related protein complex 4 subunit sigma 1 | |||||
Publication Statistics
PubMed Score 8.25
PubMed score by year
PubTator Score 4.18
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (2)
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