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Tdark
AP4S1
AP-4 complex subunit sigma-1

Protein Summary
Description
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216366
  • ENSP00000216366
  • ENSG00000100478
  • ENST00000313566
  • ENSP00000322508
  • ENST00000334725
  • ENSP00000334484
  • ENST00000542754
  • ENSP00000438170
  • ENST00000554345
  • ENSP00000450768
  • ENST00000616371
  • ENSP00000477631
  • ENST00000622409
  • ENSP00000482876

Symbol
  • AP47B
  • CLA20
  • CPSQ6
  • SPG52
  • CLAPS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.79
transcription factor binding site profile
0.68
cell type or tissue
0.6
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
AP4B1
Tbio
Novelty:  0.08255831
p_int:  0.999999972
p_ni:  2.2e-8
p_wrong:  6e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TEPSIN
Tdark
Novelty:  0.48775142
p_int:  0.99999233
p_ni:  4.1e-8
p_wrong:  0.000007628
Score:  0.713
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.997599366
p_ni:  4.42e-7
p_wrong:  0.002400193
Data Source:  BioPlex
SUV39H2
Tchem
Family:  Epigenetic
Novelty:  0.02232167
p_int:  0.879595442
p_ni:  1.7e-8
p_wrong:  0.120404541
Score:  0.622
Data Source:  BioPlex,STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
Score:  0.997
Data Source:  Reactome,STRINGDB
AP4M1
Tbio
Novelty:  0.00142961
Score:  0.994
Data Source:  Reactome,STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.959
Data Source:  STRINGDB
AP1G2
Tbio
Novelty:  0.17203425
Score:  0.94
Data Source:  STRINGDB
AP5M1
Tbio
Novelty:  0.00684623
Score:  0.93
Data Source:  STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Lysosome Vesicle Biogenesis (R-HSA-432720)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Lysosome Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 4 subunit sigma 1
VGNC:7431
467417
Macaque
adaptor related protein complex 4 sigma 1 subunit
717146
Mouse
MGI:1337065
11782
Rat
RGD:1311990
366618
Horse
adaptor related protein complex 4 subunit sigma 1
VGNC:15391
100050137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 4 subunit sigma 1
Macaque
adaptor related protein complex 4 sigma 1 subunit
Mouse
Rat
Horse
adaptor related protein complex 4 subunit sigma 1
Publication Statistics
PubMed Score 8.25
PubMed score by year
PubTator Score 4.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title