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Tbio
MAB21L2
Protein mab-21-like 2

Protein Summary
Description
Required for several aspects of embryonic development including normal development of the eye. This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317605
  • ENSP00000324701
  • ENSG00000181541

Symbol
  • MCOPS14
  • MCSKS14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.51
histone modification site profile
0.51
PubMedID
0.47
transcription factor
0.44
microRNA
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.999999893
p_ni:  8.5e-8
p_wrong:  2.3e-8
Score:  0.84
Data Source:  BioPlex,STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
p_int:  0.999999868
p_ni:  1.32e-7
Score:  0.808
Data Source:  BioPlex,STRINGDB
MIEF1
Tbio
Novelty:  0.04096049
p_int:  0.999998927
p_ni:  1.65e-7
p_wrong:  9.08e-7
Score:  0.521
Data Source:  BioPlex,STRINGDB
PBX3
Tbio
Family:  TF
Novelty:  0.01516183
p_int:  0.99998187
p_ni:  0.00001812
p_wrong:  1e-8
Score:  0.758
Data Source:  BioPlex,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.999942232
p_ni:  0.000057765
p_wrong:  2e-9
Score:  0.687
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
p_int:  0.998558768
p_ni:  0.001441232
Score:  0.702
Data Source:  BioPlex,STRINGDB
INA
Tbio
Novelty:  0.00708581
p_int:  0.890120035
p_ni:  0.109879964
Score:  0.22
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.821477335
p_ni:  0.05893619
p_wrong:  0.119586475
Score:  0.179
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.80448308
p_ni:  0.19551692
Data Source:  BioPlex
CYP2W1
Tbio
Novelty:  0.03285348
Score:  0.685
Data Source:  STRINGDB
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
30.2
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mab-21 like 2
VGNC:48916
740842
Mouse
MGI:1346022
23937
Rat
RGD:1595520
680102
Dog
mab-21 like 2
VGNC:42911
482643
Horse
mab-21 like 2
VGNC:19880
100062495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mab-21 like 2
Mouse
Rat
Dog
mab-21 like 2
Horse
mab-21 like 2
Publication Statistics
PubMed Score 21.20
PubMed score by year
PubTator Score 5.15
PubTator score by year