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Tbio
TIMM22
Mitochondrial import inner membrane translocase subunit Tim22

Protein Classes
Protein Summary
Description
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327158
  • ENSP00000320236
  • ENSG00000177370
  • ENST00000613269
  • ENSP00000482204
  • ENSG00000278501
  • ENST00000617832
  • ENSP00000478463
  • ENSG00000277649

Symbol
  • TEX4
  • TIM22
  • TEX4
  • TIM22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
virus perturbation
0.79
histone modification site profile
0.67
cellular component
0.63
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96
heel bone mineral density
3
3
6
96
heel bone mineral density
3
3
6
96
5
5
0
1.1
74.8
5
5
0
1.1
74.8
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96
heel bone mineral density
6
96
heel bone mineral density
6
96
0
1.1
74.8
0
1.1
74.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 22
VGNC:14197
746998
Mouse
MGI:1929742
56322
Rat
RGD:68406
79463
Dog
translocase of inner mitochondrial membrane 22
VGNC:49097
480639
Horse
translocase of inner mitochondrial membrane 22
VGNC:50506
100059837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 22
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 22
Horse
translocase of inner mitochondrial membrane 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y584-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Protein-Protein Interactions (138)
1 – 10 of 138
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.994
Data Source:  STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
Score:  0.993
Data Source:  Reactome,STRINGDB
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
Score:  0.993
Data Source:  Reactome,STRINGDB
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
Score:  0.985
Data Source:  Reactome,STRINGDB
TIMM13
Tdark
Family:  Enzyme
Novelty:  0.04802297
Score:  0.983
Data Source:  STRINGDB
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
Score:  0.983
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.982
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.98
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.979
Data Source:  STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.93

PubMed score by year
PubTator Score  20.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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