Tbio TIMM22 Mitochondrial import inner membrane translocase subunit Tim22

Protein Summary

Description

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9Y584
• Q9NWI8

Gene Name

• TIMM22

Ensembl ID

• ENST00000327158
• ENSP00000320236
• ENSG00000177370
• ENST00000613269
• ENSP00000482204
• ENSG00000278501
• ENST00000617832
• ENSP00000478463
• ENSG00000277649

Symbol

• TEX4
• TIM22
• TEX4
• TIM22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
virus perturbation	0.79
histone modification site profile	0.67
cellular component	0.63
tissue sample	0.59

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Import Inner Membrane Translocase Subunit Tim22

DTO Classes

Protein / Transporter / Mitochondrial Import Inner Membrane Translocase Subunit Tim22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.66   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.66   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0