Tbio RBM7 RNA-binding protein 7

Protein Summary

Description

Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).

Uniprot Accession IDs

• Q9Y580
• B2R6K8
• Q9NUT4

Gene Name

• RBM7

Ensembl ID

• ENST00000540163
• ENSP00000439918
• ENSG00000076053

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
drug perturbation	0.71
transcription factor binding site profile	0.67
tissue	0.58
cell line	0.56

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna-binding Protein 7

DTO Classes

Protein / Nucleic Acid Binding / Rna-binding Protein 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.83   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.83   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0