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Tbio
RBM7
RNA-binding protein 7

Protein Summary
Description
Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000540163
  • ENSP00000439918
  • ENSG00000076053
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
drug perturbation
0.71
transcription factor binding site profile
0.67
tissue
0.58
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (70)
1 – 10 of 70
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999990905
p_ni: 0.000009095
Score: 0.351
Data Source: BioPlex,STRINGDB
ZCCHC8
Tbio
Novelty: 0.14887134
p_int: 0.999978683
p_ni: 0.000021317
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.999952622
p_ni: 0.000047378
Score: 0.836
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999940785
p_ni: 0.000059215
Score: 0.762
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999933258
p_ni: 0.000066743
Data Source: BioPlex
C1D
Tbio
Novelty: 0.00997109
p_int: 0.999862411
p_ni: 0.000137589
Score: 0.845
Data Source: BioPlex,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.999782582
p_ni: 0.000217418
Score: 0.923
Data Source: BioPlex,STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.999709442
p_ni: 0.000290558
Data Source: BioPlex
SLC4A1AP
Tdark
Family: Transporter
Novelty: 0.41125302
p_int: 0.99932317
p_ni: 0.00067683
Score: 0.188
Data Source: BioPlex,STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.99601635
p_ni: 0.00398365
Score: 0.914
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.63

PubMed score by year
PubTator Score  5.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer