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Tchem
RIPK3
Receptor-interacting serine/threonine-protein kinase 3

Protein Summary
Description
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcripti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216274
  • ENSP00000216274
  • ENSG00000129465
  • ENST00000554756
  • ENSP00000452328
  • ENST00000643393
  • ENSP00000495915
  • ENSG00000285379
  • ENST00000646516
  • ENSP00000495490

Symbol
  • RIP3
  • RIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus perturbation
0.85
protein domain
0.73


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.82   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.82   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
ponatinib
Rendered image for ponatinib
dabrafenib
Rendered image for dabrafenib
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
3
12
94.9
sex hormone-binding globulin measurement
6
1
6
87.5
telomere length
1
1
1
82.9
alkaline phosphatase measurement
1
1
0
11.2
79.5
apolipoprotein B measurement
1
1
1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
94.9
sex hormone-binding globulin measurement
6
87.5
telomere length
1
82.9
alkaline phosphatase measurement
0
11.2
79.5
apolipoprotein B measurement
1
75.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 3
VGNC:12602
452820
Mouse
MGI:2154952
56532
Rat
RGD:628899
246240
Horse
receptor interacting serine/threonine kinase 3
VGNC:51669
100054255
Cow
receptor interacting serine/threonine kinase 3
VGNC:52818
507427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 3
Mouse
Rat
Horse
receptor interacting serine/threonine kinase 3
Cow
receptor interacting serine/threonine kinase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y572-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IKK complex recruitment mediated by RIP1
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MyD88-independent TLR4 cascade
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IKK complex recruitment mediated by RIP1
Immune System
Innate Immune System
MyD88-independent TLR4 cascade
Gene Ontology Terms (38)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (96)
1 – 10 of 96
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.977212549
p_ni:  0.022787451
Score:  0.242
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.947664383
p_ni:  0.052335617
Data Source:  BioPlex
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.994
Data Source:  Reactome,STRINGDB
MLKL
Tchem
Family:  Kinase
Novelty:  0.00327224
Score:  0.989
Data Source:  Reactome,STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.985
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.984
Data Source:  STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.973
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.968
Data Source:  STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.968
Data Source:  STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
Score:  0.965
Data Source:  STRINGDB
Publication Statistics
PubMed Score  405.82

PubMed score by year
PubTator Score  214.91

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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