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Tbio
HSPB11
Intraflagellar transport protein 25 homolog

Protein Summary
Description
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000194214
  • ENSP00000194214
  • ENSG00000081870

Symbol
  • C1orf41
  • IFT25
  • PP25
  • IFT25
  • C1orf41
  • HSPCO34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
transcription factor perturbation
0.74
tissue sample
0.69
histone modification site profile
0.67
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (110)
1 – 10 of 110
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.99998074
p_ni:  0.00001926
Score:  0.999
Data Source:  BioPlex,STRINGDB
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.924548622
p_ni:  0.075451378
Score:  0.99
Data Source:  BioPlex,STRINGDB
IFT74
Tbio
Novelty:  0.07195266
Score:  0.987
Data Source:  STRINGDB
IFT80
Tbio
Novelty:  0.04862973
Score:  0.983
Data Source:  STRINGDB
IFT46
Tdark
Novelty:  0.11310911
Score:  0.981
Data Source:  STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.981
Data Source:  STRINGDB
IFT52
Tbio
Novelty:  0.04183122
Score:  0.98
Data Source:  STRINGDB
IFT81
Tbio
Novelty:  0.01610195
Score:  0.98
Data Source:  STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
Score:  0.979
Data Source:  STRINGDB
TTC26
Tbio
Novelty:  0.10088384
Score:  0.973
Data Source:  STRINGDB
Pathways (8)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
1
1
81.1
hormone measurement
1
1
3
80.4
gut microbiome measurement
1
1
0
3.6
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
81.1
hormone measurement
3
80.4
gut microbiome measurement
0
3.6
24.5
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920188
72938
Rat
RGD:1596413
685284
Dog
heat shock protein family B (small) member 11
VGNC:53414
100683945
Horse
heat shock protein family B (small) member 11
VGNC:50706
100629783
Cow
heat shock protein family B (small) member 11
616194
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
heat shock protein family B (small) member 11
Horse
heat shock protein family B (small) member 11
Cow
heat shock protein family B (small) member 11
Publication Statistics
PubMed Score 32.78
PubMed score by year
PubTator Score 7.11
PubTator score by year