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Tdark
HES2
Transcription factor HES-2

Protein Summary
Description
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377834
  • ENSP00000367065
  • ENSG00000069812
  • ENST00000377836
  • ENSP00000367067
  • ENST00000377837
  • ENSP00000367068

Symbol
  • BHLHB40
  • bHLHb40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.63
cell type or tissue
0.59
disease
0.59
biological process
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (14)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (5)
1 – 5 of 5
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
Score: 0.501
Data Source: STRINGDB
RGS20
Tbio
Novelty: 0.04087618
Score: 0.47
Data Source: STRINGDB
BHLHE41
Tbio
Family: TF
Novelty: 0.01015053
Score: 0.443
Data Source: STRINGDB
CD99L2
Tbio
Novelty: 0.11041595
Score: 0.407
Data Source: STRINGDB
GIPC3
Tbio
Novelty: 0.14970604
Score: 0.404
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.50

PubMed score by year
PubTator Score  13.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer