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Tdark
TMEM184B
Transmembrane protein 184B

Protein Summary
Description
May activate the MAP kinase signaling pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361684
  • ENSP00000354441
  • ENSG00000198792
  • ENST00000361906
  • ENSP00000355210

Symbol
  • C22orf5
  • FM08
  • HS5O6A
  • C22orf5
  • HSPC256
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
microRNA
0.68
virus perturbation
0.68
tissue
0.62
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
1 – 10 of 53
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
REN
Tclin
Family:  Enzyme
Novelty:  0.00002435
p_int:  0.999999252
p_ni:  7.48e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999998372
p_ni:  0.000001628
Data Source:  BioPlex
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.9958767
p_ni:  0.004123296
p_wrong:  3e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.984960714
p_ni:  0.014594815
p_wrong:  0.000444471
Data Source:  BioPlex
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.982097088
p_ni:  0.01790291
p_wrong:  2e-9
Data Source:  BioPlex
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.977082527
p_ni:  0.022917473
Score:  0.161
Data Source:  BioPlex,STRINGDB
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
p_int:  0.971181302
p_ni:  0.028818698
Score:  0.165
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.971068297
p_ni:  0.028472361
p_wrong:  0.000459342
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.970274787
p_ni:  0.029352196
p_wrong:  0.000373017
Data Source:  BioPlex
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
6
11
1.5
93.8
glomerular filtration rate
4
5
4
6.3
93.2
high density lipoprotein cholesterol measurement
3
3
4
91.5
serum alanine aminotransferase measurement
2
2
1
6.9
80
apolipoprotein A 1 measurement
1
1
1
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
1.5
93.8
glomerular filtration rate
4
6.3
93.2
high density lipoprotein cholesterol measurement
4
91.5
serum alanine aminotransferase measurement
1
6.9
80
apolipoprotein A 1 measurement
1
76
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 184B
VGNC:5996
743713
Macaque
transmembrane protein 184B
700445
Mouse
MGI:2445179
223693
Rat
RGD:1306591
362959
Dog
transmembrane protein 184B
VGNC:47509
481254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 184B
Macaque
transmembrane protein 184B
Mouse
Rat
Dog
transmembrane protein 184B
Publication Statistics
PubMed Score 4.12
PubMed score by year
PubTator Score 0.50
PubTator score by year