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Tbio
SAMM50
Sorting and assembly machinery component 50 homolog

Protein Summary
Description
Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350028
  • ENSP00000345445
  • ENSG00000100347

Symbol
  • SAM50
  • OMP85
  • SAM50
  • TOB55
  • TRG-3
  • CGI-51
  • YNL026W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.9
histone modification site profile
0.88
virus perturbation
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.07   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.07   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.5
94.7
1
1
1
33.8
total cholesterol measurement
1
1
1
29.4
osteoprotegerin measurement
1
1
1
16.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
94.7
1
33.8
total cholesterol measurement
1
29.4
osteoprotegerin measurement
1
16.7
Pathways (5)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Reactome
Organelle biogenesis and maintenance
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Mitochondrial protein import
Organelle biogenesis and maintenance
Protein localization
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (121)
1 – 10 of 121
MTX2
Tbio
Novelty: 0.02047483
p_int: 0.98657066
p_ni: 0.01342934
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.951245315
p_ni: 0.048754685
Data Source: BioPlex
CHCHD6
Tbio
Novelty: 0.12379343
Score: 0.997
Data Source: STRINGDB
IMMT
Tbio
Novelty: 0.00260309
Score: 0.996
Data Source: STRINGDB
CHCHD3
Tbio
Novelty: 0.05341939
Score: 0.995
Data Source: STRINGDB
TOMM40
Tbio
Novelty: 0.0041507
Score: 0.994
Data Source: STRINGDB
MTX1
Tbio
Novelty: 0.02350764
Score: 0.991
Data Source: Reactome,STRINGDB
MINOS1
Tdark
Novelty: 0.40437095
Score: 0.982
Data Source: STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.978
Data Source: STRINGDB
MIC13
Tbio
Novelty: 0.03686888
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.07

PubMed score by year
PubTator Score  58.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer