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Tbio
RNF114
E3 ubiquitin-protein ligase RNF114

Protein Summary
Description
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244061
  • ENSP00000244061
  • ENSG00000124226

Symbol
  • ZNF228
  • ZNF313
  • ZNF313
  • PSORS12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.98
transcription factor perturbation
0.98
protein domain
0.85
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
71.9
psoriasis vulgaris
1
1
0
1.2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
71.9
psoriasis vulgaris
0
1.2
49.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 114
VGNC:52090
470029
Macaque
ring finger protein 114
713517
Mouse
MGI:1933159
81018
Rat
RGD:1303139
362277
Dog
ring finger protein 114
VGNC:45623
477261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 114
Macaque
ring finger protein 114
Mouse
Rat
Dog
ring finger protein 114
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y508-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (313)
1 – 10 of 313
IDI2
Tbio
Family: Enzyme
Novelty: 0.02715208
p_int: 0.99531165
p_ni: 0.00459404
p_wrong: 0.00009431
Score: 0.187
Data Source: BioPlex,STRINGDB
TIPARP
Tbio
Family: Enzyme
Novelty: 0.00433138
p_int: 0.993747089
p_ni: 0.006252745
p_wrong: 1.66e-7
Data Source: BioPlex
UBE2D1
Tbio
Novelty: 0.00865867
p_int: 0.987647767
p_ni: 0.01235222
p_wrong: 1.3e-8
Score: 0.939
Data Source: BioPlex,STRINGDB
PARP12
Tbio
Family: Enzyme
Novelty: 0.08076657
p_int: 0.987384483
p_ni: 0.012615517
Score: 0.694
Data Source: BioPlex,STRINGDB
PARP11
Tbio
Family: Enzyme
Novelty: 0.11901686
p_int: 0.985191913
p_ni: 0.014808087
Score: 0.831
Data Source: BioPlex,STRINGDB
AUP1
Tbio
Novelty: 0.0418459
p_int: 0.96924771
p_ni: 0.030752268
p_wrong: 2.3e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
p_int: 0.953954786
p_ni: 0.046045214
Score: 0.932
Data Source: BioPlex,STRINGDB
CD93
Tbio
Novelty: 0.01324003
p_int: 0.948130121
p_ni: 0.051869879
Score: 0.167
Data Source: BioPlex,STRINGDB
DTX3
Tbio
Family: Enzyme
Novelty: 0.06212096
p_int: 0.942620117
p_ni: 0.057379874
p_wrong: 9e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
TNFAIP3
Tbio
Novelty: 0.00257088
p_int: 0.879440635
p_ni: 0.120559359
p_wrong: 6e-9
Score: 0.731
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.66

PubMed score by year
PubTator Score  11.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer