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Tbio
LSM4
U6 snRNA-associated Sm-like protein LSm4

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000593829
  • ENSP00000469468
  • ENSG00000130520

Symbol
  • GRP
  • YER112W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor binding site profile
0.96
kinase perturbation
0.93
co-expressed gene
0.69
small molecule perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (315)
1 – 10 of 315
LSM3
Tbio
Novelty: 0.10679982
p_int: 0.999862118
p_ni: 0.000137882
Score: 0.999
Data Source: BioPlex,STRINGDB
LSM5
Tbio
Novelty: 0.09756098
p_int: 0.999773897
p_ni: 0.000226103
Score: 0.999
Data Source: BioPlex,STRINGDB
LSM6
Tdark
Novelty: 0.24061873
p_int: 0.998984377
p_ni: 0.001015618
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
LSM7
Tbio
Novelty: 0.0977271
p_int: 0.997851916
p_ni: 0.002148084
Score: 0.999
Data Source: BioPlex,STRINGDB
PRPF3
Tbio
Novelty: 0.01841457
p_int: 0.976646621
p_ni: 0.023353379
Score: 0.999
Data Source: BioPlex,STRINGDB
SART3
Tbio
Novelty: 0.02812047
p_int: 0.939122907
p_ni: 0.060877093
Score: 0.981
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.00241221
p_int: 0.936562268
p_ni: 0.063437732
Score: 0.996
Data Source: BioPlex,STRINGDB
PRPF4
Tchem
Novelty: 0.15261686
p_int: 0.86056252
p_ni: 0.13943748
Score: 0.996
Data Source: BioPlex,STRINGDB
LSM1
Tbio
Novelty: 0.00857865
Score: 0.999
Data Source: STRINGDB
SNRPF
Tdark
Novelty: 0.22699635
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.74

PubMed score by year
PubTator Score  17.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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