Tbio LSM5 U6 snRNA-associated Sm-like protein LSm5

Protein Summary

Description

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9Y4Y9

Gene Name

• LSM5

Ensembl ID

• ENST00000409292
• ENSP00000386814
• ENSG00000106355
• ENST00000409782
• ENSP00000387109
• ENST00000409909
• ENSP00000386363
• ENST00000409952
• ENSP00000387126
• ENST00000410044
• ENSP00000386707
• ENST00000450169
• ENSP00000410758

Symbol

• YER146W

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.72
transcription factor binding site profile	0.72
transcription factor perturbation	0.61
kinase perturbation	0.6
small molecule perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U6 Snrna-associated Sm-like Protein Lsm5

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U6 Snrna-associated Sm-like Protein Lsm5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.13   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.13   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0