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Tbio
ARIH1
E3 ubiquitin-protein ligase ARIH1

Protein Summary
Description
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 ca ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379887
  • ENSP00000369217
  • ENSG00000166233

Symbol
  • ARI
  • MOP6
  • UBCH7BP
  • ARI
  • HARI
  • HHARI
  • UBCH7BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.96
transcription factor binding site profile
0.95
histone modification site profile
0.78
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (174)
1 – 10 of 174
FBXW2
Tbio
Novelty: 0.01492058
p_int: 0.999999929
p_ni: 6.7e-8
p_wrong: 4e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
SELENOH
Tbio
Novelty: 0.02421467
p_int: 0.999999758
p_ni: 2.33e-7
p_wrong: 9e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.999999595
p_ni: 4.04e-7
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999999266
p_ni: 7.34e-7
Data Source: BioPlex
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.999993715
p_ni: 0.000006283
p_wrong: 1e-9
Score: 0.668
Data Source: BioPlex,STRINGDB
CRAMP1
Tdark
Novelty: 0.26519971
p_int: 0.999992772
p_ni: 0.000007223
p_wrong: 5e-9
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.999991184
p_ni: 0.000008816
Data Source: BioPlex
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999987887
p_ni: 0.000012113
Data Source: BioPlex
HOXC9
Tbio
Family: TF
Novelty: 0.02524418
p_int: 0.999987332
p_ni: 0.000012652
p_wrong: 1.5e-8
Data Source: BioPlex
JUND
Tbio
Family: TF
Novelty: 0.00277701
p_int: 0.999985779
p_ni: 0.00001422
p_wrong: 1e-9
Score: 0.442
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.21

PubMed score by year
PubTator Score  65.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer