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Tbio
KLF12
Krueppel-like factor 12

Protein Summary
Description
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377669
  • ENSP00000366897
  • ENSG00000118922

Symbol
  • AP2REP
  • AP2REP
  • AP-2rep
  • HSPC122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.95
trait
0.93
kinase perturbation
0.84
molecular function
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.08   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.08   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
5
85.1
electrocardiography
1
1
64
66.8
Familial long QT syndrome
1
1
0
1.3
42.4
refractive error measurement
1
1
1
40.1
energy expenditure measurement
1
1
0
53
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
85.1
electrocardiography
64
66.8
Familial long QT syndrome
0
1.3
42.4
refractive error measurement
1
40.1
energy expenditure measurement
0
53
36
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Kruppel like factor 12
694575
Mouse
MGI:1333796
16597
Rat
RGD:1309204
306110
Dog
Kruppel like factor 12
VGNC:42432
485493
Horse
Kruppel like factor 12
VGNC:19442
100066348
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Kruppel like factor 12
Mouse
Rat
Dog
Kruppel like factor 12
Horse
Kruppel like factor 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4X4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (28)
1 – 10 of 28
IDO2
Tchem
Family: Enzyme
Novelty: 0.01141558
p_int: 0.793741509
p_ni: 0.00002725
p_wrong: 0.206231241
Score: 0.622
Data Source: BioPlex,STRINGDB
TFAP2A
Tbio
Family: TF
Novelty: 0.00235655
Score: 0.711
Data Source: STRINGDB
MAGEB10
Tdark
Novelty: 2.96156972
Score: 0.669
Data Source: STRINGDB
TANC2
Tdark
Novelty: 0.08495328
Score: 0.591
Data Source: STRINGDB
FSBP
Tdark
Novelty: 0.0676606
Score: 0.583
Data Source: STRINGDB
FRMD4A
Tbio
Novelty: 0.10960581
Score: 0.569
Data Source: STRINGDB
ZNF827
Tdark
Family: TF
Novelty: 0.22115243
Score: 0.565
Data Source: STRINGDB
PARD3B
Tbio
Novelty: 0.09155541
Score: 0.552
Data Source: STRINGDB
SRBD1
Tbio
Novelty: 0.18931356
Score: 0.543
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.538
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.08

PubMed score by year
PubTator Score  21.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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