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Tbio
CCL27
C-C motif chemokine 27

Protein Summary
Description
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259631
  • ENSP00000259631
  • ENSG00000213927

Symbol
  • ILC
  • SCYA27
  • ALP
  • ILC
  • CTAK
  • CTACK
  • PESKY
  • ESKINE
  • SCYA27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
tissue
0.56
small molecule perturbation
0.55
tissue sample
0.55
biological term
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.49   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.49   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 27
VGNC:13862
100610389
Mouse
100861978
Rat
RGD:1304660
362505
Dog
C-C motif chemokine ligand 27
VGNC:38889
445454
Cow
C-C motif chemokine ligand 27
VGNC:26952
101902682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 27
Mouse
Rat
Dog
C-C motif chemokine ligand 27
Cow
C-C motif chemokine ligand 27
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4X3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (305)
1 – 10 of 305
CCR10
Tchem
Family: GPCR
Novelty: 0.014331
Score: 0.99
Data Source: Reactome,STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.977
Data Source: STRINGDB
CCL25
Tbio
Novelty: 0.00824289
Score: 0.976
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.961
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.956
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.955
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.955
Data Source: STRINGDB
CCL19
Tbio
Novelty: 0.00169711
Score: 0.953
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.953
Data Source: STRINGDB
CCL13
Tbio
Novelty: 0.00593527
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  601.49

PubMed score by year
PubTator Score  91.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer