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Tbio
LAS1L
Ribosomal biogenesis protein LAS1L

Protein Summary
Description
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374804
  • ENSP00000363937
  • ENSG00000001497
  • ENST00000374807
  • ENSP00000363940
  • ENST00000374811
  • ENSP00000363944
  • ENST00000484069
  • ENSP00000473471

Symbol
  • WTS
  • Las1-like
  • dJ475B7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
disease perturbation
0.87
transcription factor perturbation
0.84
kinase perturbation
0.76
cellular component
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LAS1 like, ribosome biogenesis factor
VGNC:12466
473645
Macaque
LAS1 like, ribosome biogenesis factor
709053
Mouse
MGI:1923380
76130
Rat
RGD:1565755
296865
Dog
LAS1 like, ribosome biogenesis factor
VGNC:42594
480941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LAS1 like, ribosome biogenesis factor
Macaque
LAS1 like, ribosome biogenesis factor
Mouse
Rat
Dog
LAS1 like, ribosome biogenesis factor
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (210)
1 – 10 of 210
NOL9
Tdark
Family: Enzyme
Novelty: 0.05830272
Score: 0.999
Data Source: STRINGDB
PELP1
Tbio
Novelty: 0.00817675
Score: 0.999
Data Source: STRINGDB
TEX10
Tdark
Novelty: 0.12988812
Score: 0.998
Data Source: STRINGDB
WDR18
Tbio
Novelty: 0.03015818
Score: 0.998
Data Source: STRINGDB
SENP3
Tbio
Family: Enzyme
Novelty: 0.00374663
Score: 0.981
Data Source: STRINGDB
WDR3
Tbio
Novelty: 0.15410886
Score: 0.963
Data Source: STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
Score: 0.957
Data Source: STRINGDB
PES1
Tbio
Novelty: 0.07162845
Score: 0.953
Data Source: STRINGDB
EXOSC2
Tbio
Novelty: 0.08163283
Score: 0.948
Data Source: STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.32

PubMed score by year
PubTator Score  4.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer