Tbio LAS1L Ribosomal biogenesis protein LAS1L

Protein Summary

Description

Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Uniprot Accession IDs

• Q9Y4W2
• A9X410
• Q5JXQ0
• Q8TEN5
• Q9H9V5

Gene Name

• LAS1L

Ensembl ID

• ENST00000374804
• ENSP00000363937
• ENSG00000001497
• ENST00000374807
• ENSP00000363940
• ENST00000374811
• ENSP00000363944
• ENST00000484069
• ENSP00000473471

Symbol

• WTS
• Las1-like
• dJ475B7.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
disease perturbation	0.87
transcription factor perturbation	0.84
kinase perturbation	0.76
cellular component	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0