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Tbio
TELO2
Telomere length regulation protein TEL2 homolog

Protein Summary
Description
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262319
  • ENSP00000262319
  • ENSG00000100726

Symbol
  • KIAA0683
  • CLK2
  • TEL2
  • YHFS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
interacting protein
0.75
hub protein
0.67
tissue sample
0.66
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.41   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.41   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
2
2
74.7
heel bone mineral density
2
2
2
58.9
femoral neck bone mineral density
1
1
1
24.3
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
2
74.7
heel bone mineral density
2
58.9
femoral neck bone mineral density
1
24.3
1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomere maintenance 2
VGNC:13795
453818
Mouse
MGI:1918968
71718
Rat
RGD:1305553
302986
Dog
telomere maintenance 2
VGNC:47245
490076
Horse
telomere maintenance 2
VGNC:23997
100067764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomere maintenance 2
Mouse
Rat
Dog
telomere maintenance 2
Horse
telomere maintenance 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4R8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
BSG
Tbio
Novelty:  0.0010285
p_int:  0.998165587
p_ni:  0.001834413
Score:  0.191
Data Source:  BioPlex,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.950493157
p_ni:  0.049506843
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.847120061
p_ni:  0.152879939
Data Source:  BioPlex
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.79724415
p_ni:  0.20275585
Score:  0.183
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.781671982
p_ni:  0.218328018
Data Source:  BioPlex
FANCM
Tbio
Novelty:  0.01122278
Score:  0.998
Data Source:  STRINGDB
TTI1
Tbio
Novelty:  0.05516406
Score:  0.997
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.984
Data Source:  STRINGDB
FAAP24
Tbio
Novelty:  0.08081633
Score:  0.971
Data Source:  STRINGDB
MLST8
Tbio
Novelty:  0.00423122
Score:  0.968
Data Source:  STRINGDB
Publication Statistics
PubMed Score  19.41

PubMed score by year
PubTator Score  5.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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