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Tbio
TTLL3
Tubulin monoglycylase TTLL3

Protein Summary
Description
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383827
  • ENSP00000373338
  • ENSG00000214021
  • ENST00000430793
  • ENSP00000403874
  • ENST00000438141
  • ENSP00000409246

Symbol
  • HOTTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
histone modification site profile
0.79
tissue
0.6
tissue sample
0.6
cell line
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 3
VGNC:12219
461033
Mouse
MGI:2141418
101100
Rat
RGD:1311255
362415
Zebrafish
ZDB-GENE-060616-182
724000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 3
Mouse
Rat
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4R7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (40)
1 – 10 of 40
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.985874428
p_ni: 0.014125572
Score: 0.375
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.92790731
p_ni: 0.07209269
Score: 0.663
Data Source: BioPlex,STRINGDB
SUFU
Tbio
Novelty: 0.00475249
p_int: 0.895957942
p_ni: 0.103192856
p_wrong: 0.000849201
Score: 0.195
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.887094759
p_ni: 0.112905241
Score: 0.58
Data Source: BioPlex,STRINGDB
CCT4
Tbio
Novelty: 0.01176123
p_int: 0.850371284
p_ni: 0.149628716
Score: 0.539
Data Source: BioPlex,STRINGDB
TCP1
Tbio
Novelty: 0.00395241
p_int: 0.815327864
p_ni: 0.184672136
Score: 0.542
Data Source: BioPlex,STRINGDB
CCT6A
Tbio
Novelty: 0.02368046
p_int: 0.796070604
p_ni: 0.203929396
Score: 0.469
Data Source: BioPlex,STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
Score: 0.587
Data Source: STRINGDB
CFAP221
Tbio
Novelty: 0.14501712
Score: 0.583
Data Source: STRINGDB
CCDC39
Tbio
Novelty: 0.0150835
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.20

PubMed score by year
PubTator Score  0.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer