Tchem ATG4B Cysteine protease ATG4B

Protein Summary

Description

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y4P1
• B7WNK2
• Q53NU4
• Q6ZUV8
• Q8WYM9
• Q96K07
• Q96K96
• Q96SZ1
• Q9Y2F2

Gene Name

• ATG4B

Ensembl ID

• ENST00000402096
• ENSP00000384661
• ENSG00000168397
• ENST00000404914
• ENSP00000384259
• ENST00000405546
• ENSP00000383964

Symbol

• APG4B
• AUTL1
• KIAA0943
• APG4B
• AUTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.95
interacting protein	0.93
histone modification site profile	0.76
biological process	0.73

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Cysteine Protease Atg4b

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cysteine Protease Atg4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.37   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 596   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.37   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0