Protein Summary
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is ...more
- ENST00000402096
- ENSP00000384661
- ENSG00000168397
- ENST00000404914
- ENSP00000384259
- ENST00000405546
- ENSP00000383964
- APG4B
- AUTL1
- KIAA0943
- APG4B
- AUTL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 0.95 | ||
interacting protein | 0.93 | ||
histone modification site profile | 0.76 | ||
biological process | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.43 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 596 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.43 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 596 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (25)
Protein-Protein Interactions (102)
FANK1
Novelty: 0.12389783
p_int: 0.999999099
p_ni: 3.56e-7
p_wrong: 5.45e-7
Score: 0.555
Data Source: BioPlex,STRINGDB
STK16
Family: Kinase
Novelty: 0.01499094
p_int: 0.999993406
p_ni: 0.00000353
p_wrong: 0.000003065
Score: 0.269
Data Source: BioPlex,STRINGDB
CARTPT
Novelty: 0.00224864
p_int: 0.920494128
p_ni: 0.030229643
p_wrong: 0.049276229
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Macroautophagy | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Macroautophagy | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (2)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 2 | 2 | 1.1 | 90.7 | |||||
eosinophil count | 3 | 1 | 3 | 86.9 | |||||
10 | 1 | 0 | 1.1 | 86.2 | |||||
eosinophil percentage of leukocytes | 2 | 1 | 2 | 86.1 | |||||
childhood onset asthma | 2 | 1 | 0 | 1.2 | 86.1 | ||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.1 | 90.7 | |||||
eosinophil count | 3 | 86.9 | |||||
0 | 1.1 | 86.2 | |||||
eosinophil percentage of leukocytes | 2 | 86.1 | |||||
childhood onset asthma | 0 | 1.2 | 86.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | autophagy related 4B cysteine peptidase | VGNC:99 | 748674 | |||||
Macaque | autophagy related 4B cysteine peptidase | 717813 | ||||||
Mouse | MGI:1913865 | 66615 | ||||||
Rat | RGD:1309664 | 316640 | ||||||
Dog | autophagy related 4B cysteine peptidase | VGNC:49762 | 609599 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | autophagy related 4B cysteine peptidase | |||||
Macaque | autophagy related 4B cysteine peptidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | autophagy related 4B cysteine peptidase | |||||
Publication Statistics
PubMed Score 122.43
PubMed score by year
PubTator Score 51.57
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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