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Tbio
RNF115
E3 ubiquitin-protein ligase RNF115

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000582693
  • ENSP00000463650
  • ENSG00000265491

Symbol
  • ZNF364
  • BCA2
  • ZNF364
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.91
virus perturbation
0.83
histone modification site profile
0.73
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.62   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.62   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.973624059
p_ni:  0.026375366
p_wrong:  5.76e-7
Score:  0.922
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.955480614
p_ni:  0.044519386
Score:  0.72
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.901450777
p_ni:  0.098406376
p_wrong:  0.000142847
Data Source:  BioPlex
PSEN2
Tchem
Family:  Enzyme
Novelty:  0.00112188
p_int:  0.896323219
p_ni:  0.103676065
p_wrong:  7.17e-7
Score:  0.359
Data Source:  BioPlex,STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
p_int:  0.88257584
p_ni:  0.117285833
p_wrong:  0.000138327
Data Source:  BioPlex
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
p_int:  0.820854504
p_ni:  0.178447925
p_wrong:  0.000697571
Score:  0.199
Data Source:  BioPlex,STRINGDB
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.786861137
p_ni:  0.212833919
p_wrong:  0.000304944
Score:  0.735
Data Source:  BioPlex,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.98
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.97
Data Source:  STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
9
13
3.3
99.3
uric acid measurement
4
4
7
93.1
myeloid white cell count
1
1
1
68.8
high density lipoprotein cholesterol measurement
1
2
2
54.2
apolipoprotein A 1 measurement
1
2
2
52.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
13
3.3
99.3
uric acid measurement
7
93.1
myeloid white cell count
1
68.8
high density lipoprotein cholesterol measurement
2
54.2
apolipoprotein A 1 measurement
2
52.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 115
VGNC:1495
457980
Macaque
ring finger protein 115
697067
Mouse
MGI:1915095
67845
Rat
RGD:1305315
362002
Dog
ring finger protein 115
VGNC:45624
612818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 115
Macaque
ring finger protein 115
Mouse
Rat
Dog
ring finger protein 115
Publication Statistics
PubMed Score 35.62
PubMed score by year
PubTator Score 18.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title