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Tbio
HYOU1
Hypoxia up-regulated protein 1

Protein Summary
Description
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617285
  • ENSP00000480150
  • ENSG00000149428
  • ENST00000630669
  • ENSP00000486825
  • ENSG00000280682

Symbol
  • GRP170
  • ORP150
  • IMD59
  • Grp170
  • HSP12A
  • ORP150
  • GRP-170
  • ORP-150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
disease perturbation
0.87
transcription factor perturbation
0.8
molecular function
0.79
biological process
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.86   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.86   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (216)
1 – 10 of 216
LAMA3
Tbio
Novelty:  0.00733792
p_int:  0.999839415
p_ni:  0.000160584
p_wrong:  1e-9
Data Source:  BioPlex
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.999752857
p_ni:  0.000247142
p_wrong:  1e-9
Data Source:  BioPlex
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
p_int:  0.999696309
p_ni:  0.000302064
p_wrong:  0.000001627
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.999600814
p_ni:  0.000399186
Data Source:  BioPlex
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.999431336
p_ni:  0.000568664
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.999144231
p_ni:  0.000853677
p_wrong:  0.000002093
Data Source:  BioPlex
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.998960686
p_ni:  0.001039314
Data Source:  BioPlex
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.998645293
p_ni:  0.001354707
Data Source:  BioPlex
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.998329937
p_ni:  0.001670063
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.997926495
p_ni:  0.001797223
p_wrong:  0.000276282
Data Source:  BioPlex
Pathways (8)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Scavenging by Class F Receptors
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
IRE1alpha activates chaperones
Metabolism of proteins
Scavenging by Class F Receptors
Unfolded Protein Response (UPR)
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
86.7
body mass index
3
3
3
79.5
waist-hip ratio
2
2
2
75
serum albumin measurement
1
2
2
74
high density lipoprotein cholesterol measurement
1
1
1
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
86.7
body mass index
3
79.5
waist-hip ratio
2
75
serum albumin measurement
2
74
high density lipoprotein cholesterol measurement
1
73.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hypoxia up-regulated 1
707715
Mouse
MGI:108030
12282
Rat
RGD:621146
192235
Dog
hypoxia up-regulated 1
VGNC:53417
479410
Horse
hypoxia up-regulated 1
VGNC:49330
100071323
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hypoxia up-regulated 1
Mouse
Rat
Dog
hypoxia up-regulated 1
Horse
hypoxia up-regulated 1
Publication Statistics
PubMed Score 139.86
PubMed score by year
PubTator Score 68.38
PubTator score by year