You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5

Protein Summary
Description
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000013125
  • ENSP00000013125
  • ENSG00000012983

Symbol
  • KHS
  • GCKR
  • KHS1
  • MAPKKKK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.85
small molecule
0.8
transcription factor binding site profile
0.78
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
73.5
hemoglobin measurement
2
1
2
68.4
body fat distribution
2
1
5
61.4
mean platelet volume
1
1
1
28.7
heel bone mineral density
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
73.5
hemoglobin measurement
2
68.4
body fat distribution
5
61.4
mean platelet volume
1
28.7
heel bone mineral density
1
20.5
Protein-Protein Interactions (34)
1 – 10 of 34
CDRT15
Tdark
Novelty: 1.16705127
p_int: 0.999999995
p_ni: 4e-9
Score: 0.513
Data Source: BioPlex,STRINGDB
MAP4K3
Tchem
Family: Kinase
Novelty: 0.04596429
p_int: 0.999990388
p_ni: 0.000009144
p_wrong: 4.68e-7
Score: 0.655
Data Source: BioPlex,STRINGDB
EIF1AD
Tdark
Novelty: 0.23915521
p_int: 0.999973343
p_ni: 0.0000128
p_wrong: 0.000013858
Data Source: BioPlex
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999943946
p_ni: 0.000026521
p_wrong: 0.000029533
Score: 0.499
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.968
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.923
Data Source: STRINGDB
MAP3K1
Tchem
Family: Kinase
Novelty: 0.0041131
Score: 0.92
Data Source: STRINGDB
MAP3K11
Tchem
Family: Kinase
Novelty: 0.01112378
Score: 0.911
Data Source: STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00144614
Score: 0.907
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.14

PubMed score by year
PubTator Score  6.31

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: