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Tbio
CRYBG1
Beta/gamma crystallin domain-containing protein 1

Protein Summary
Description
May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369066
  • ENSP00000358062
  • ENSG00000112297

Symbol
  • AIM1
  • ST4
  • AIM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999997387
p_ni:  0.000002613
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999976892
p_ni:  0.000023108
Score:  0.177
Data Source:  BioPlex,STRINGDB
ZNF829
Tdark
Family:  TF
Novelty:  0.99
p_int:  0.999954928
p_ni:  0.000045072
Score:  0.403
Data Source:  BioPlex,STRINGDB
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999150161
p_ni:  0.000849831
p_wrong:  8e-9
Data Source:  BioPlex
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.998761515
p_ni:  0.001238478
p_wrong:  7e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.997171989
p_ni:  0.002573946
p_wrong:  0.000254066
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.993129909
p_ni:  0.0038454
p_wrong:  0.00302469
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99143599
p_ni:  0.008542314
p_wrong:  0.000021696
Data Source:  BioPlex
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
MMP11
Tchem
Novelty:  0.0014914
Score:  0.727
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
56.6
visceral adipose tissue measurement
1
1
4
39.6
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
56.6
visceral adipose tissue measurement
4
39.6
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin beta-gamma domain containing 1
VGNC:2637
462906
Macaque
crystallin beta-gamma domain containing 1
697117
Mouse
MGI:109544
11630
Dog
crystallin beta-gamma domain containing 1
VGNC:39642
475012
Cow
crystallin beta-gamma domain containing 1
VGNC:27739
526200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin beta-gamma domain containing 1
Macaque
crystallin beta-gamma domain containing 1
Mouse
Dog
crystallin beta-gamma domain containing 1
Cow
crystallin beta-gamma domain containing 1
Publication Statistics
PubMed Score 18.46
PubMed score by year
PubTator Score 140.14
PubTator score by year
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Related Publications
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PMID
Year
Title