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Tbio
LOXL2
Lysyl oxidase homolog 2

Protein Summary
Description
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389131
  • ENSP00000373783
  • ENSG00000134013

Symbol
  • LOR
  • LOR2
  • WS9-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.9
biological process
0.89
PubMedID
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.41   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.41   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
64.7
body height
1
1
1
57.7
blood protein measurement
1
1
1
30.8
central corneal thickness
1
1
0
2.4
20.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
64.7
body height
1
57.7
blood protein measurement
1
30.8
central corneal thickness
0
2.4
20.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (100)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.999467121
p_ni: 0.000532867
p_wrong: 1.2e-8
Data Source: BioPlex
RBM14
Tbio
Novelty: 0.01286049
p_int: 0.999274461
p_ni: 0.000725536
p_wrong: 3e-9
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.997871404
p_ni: 0.002128575
p_wrong: 2.1e-8
Data Source: BioPlex
MFAP5
Tbio
Novelty: 0.01839035
p_int: 0.99772418
p_ni: 0.002275428
p_wrong: 3.93e-7
Score: 0.907
Data Source: BioPlex,STRINGDB
KLK11
Tbio
Family: Enzyme
Novelty: 0.00267977
p_int: 0.995782846
p_ni: 0.004217154
Data Source: BioPlex
CSTL1
Tbio
Novelty: 0.13370814
p_int: 0.992981367
p_ni: 0.007016735
p_wrong: 0.000001897
Data Source: BioPlex
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.991755658
p_ni: 0.008244342
Data Source: BioPlex
PSG8
Tdark
Novelty: 0.1446257
p_int: 0.991415203
p_ni: 0.008555144
p_wrong: 0.000029653
Data Source: BioPlex
TMEM87A
Tdark
Novelty: 0.33614983
p_int: 0.989351306
p_ni: 0.010646455
p_wrong: 0.000002239
Data Source: BioPlex
ADAMTS4
Tchem
Family: Enzyme
Novelty: 0.00424194
p_int: 0.988005138
p_ni: 0.011985389
p_wrong: 0.000009472
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  207.41

PubMed score by year
PubTator Score  117.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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