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Tchem
LOXL2
Lysyl oxidase homolog 2

Protein Summary
Description
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389131
  • ENSP00000373783
  • ENSG00000134013

Symbol
  • LOR
  • LOR2
  • WS9-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.9
biological process
0.89
PubMedID
0.85
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.34   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.34   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 227
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (227)
beta-aminopropionitrile
Rendered image for beta-aminopropionitrile
CHEMBL4568508,CHEMBL4444826
Rendered image for CHEMBL4568508,CHEMBL4444826
CHEMBL4569453
Rendered image for CHEMBL4569453
CHEMBL4457578
Rendered image for CHEMBL4457578
CHEMBL4515085,CHEMBL4456063
Rendered image for CHEMBL4515085,CHEMBL4456063
CHEMBL4564517
Rendered image for CHEMBL4564517
CHEMBL4531065
Rendered image for CHEMBL4531065
CHEMBL4448713
Rendered image for CHEMBL4448713
Protein-Protein Interactions (75)
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.999467121
p_ni:  0.000532867
p_wrong:  1.2e-8
Data Source:  BioPlex
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.999274461
p_ni:  0.000725536
p_wrong:  3e-9
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.997871404
p_ni:  0.002128575
p_wrong:  2.1e-8
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.99772418
p_ni:  0.002275428
p_wrong:  3.93e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
KLK11
Tbio
Family:  Enzyme
Novelty:  0.00267977
p_int:  0.995782846
p_ni:  0.004217154
Data Source:  BioPlex
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.992981367
p_ni:  0.007016735
p_wrong:  0.000001897
Data Source:  BioPlex
WNT7A
Tbio
Novelty:  0.00421662
p_int:  0.991755658
p_ni:  0.008244342
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.991415203
p_ni:  0.008555144
p_wrong:  0.000029653
Data Source:  BioPlex
TMEM87A
Tdark
Novelty:  0.33614983
p_int:  0.989351306
p_ni:  0.010646455
p_wrong:  0.000002239
Data Source:  BioPlex
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
p_int:  0.988005138
p_ni:  0.011985389
p_wrong:  0.000009472
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (100)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
88.5
body height
1
2
2
79.9
central corneal thickness
2
2
0
2.1
76.9
appendicular lean mass
2
1
2
70.6
brain measurement
1
1
0
10.6
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.5
body height
2
79.9
central corneal thickness
0
2.1
76.9
appendicular lean mass
2
70.6
brain measurement
0
10.6
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494]
Mouse
MGI:2137913
94352
Rat
RGD:1308435
290350
Dog
lysyl oxidase like 2
VGNC:42739
486118
Horse
lysyl oxidase like 2
VGNC:19724
100058083
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494]
Mouse
Rat
Dog
lysyl oxidase like 2
Horse
lysyl oxidase like 2
Publication Statistics
PubMed Score 258.34
PubMed score by year
PubTator Score 117.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title