Protein Summary
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelia ...more
- ENST00000389131
- ENSP00000373783
- ENSG00000134013
- LOR
- LOR2
- WS9-14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.91 | ||
molecular function | 0.9 | ||
biological process | 0.89 | ||
PubMedID | 0.85 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.53 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 411 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.53 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 411 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 227
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (227)
Protein-Protein Interactions (75)
LYZL2
Family: Enzyme
Novelty: 0.50542161
p_int: 0.999467121
p_ni: 0.000532867
p_wrong: 1.2e-8
Data Source: BioPlex
RBM14
Novelty: 0.01286049
p_int: 0.999274461
p_ni: 0.000725536
p_wrong: 3e-9
Data Source: BioPlex
DEFA1
Novelty: 0.01027492
p_int: 0.997871404
p_ni: 0.002128575
p_wrong: 2.1e-8
Data Source: BioPlex
MFAP5
Novelty: 0.01839035
p_int: 0.99772418
p_ni: 0.002275428
p_wrong: 3.93e-7
Score: 0.907
Data Source: BioPlex,STRINGDB
KLK11
Family: Enzyme
Novelty: 0.00267977
p_int: 0.995782846
p_ni: 0.004217154
Data Source: BioPlex
CSTL1
Novelty: 0.13370814
p_int: 0.992981367
p_ni: 0.007016735
p_wrong: 0.000001897
Data Source: BioPlex
PSG8
Novelty: 0.1446257
p_int: 0.991415203
p_ni: 0.008555144
p_wrong: 0.000029653
Data Source: BioPlex
TMEM87A
Novelty: 0.33614983
p_int: 0.989351306
p_ni: 0.010646455
p_wrong: 0.000002239
Data Source: BioPlex
ADAMTS4
Family: Enzyme
Novelty: 0.00424194
p_int: 0.988005138
p_ni: 0.011985389
p_wrong: 0.000009472
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (100)
Reactome (5)
WikiPathways (95)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen formation | ||||
Reactome | Crosslinking of collagen fibrils | ||||
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen formation | ||||
Crosslinking of collagen fibrils | ||||
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (6)
Components (8)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 2 | 2 | 77.6 | |||||
mean platelet volume | 2 | 2 | 2 | 75.5 | |||||
4 | 2 | 0 | 1.1 | 68.5 | |||||
hemoglobin measurement | 3 | 2 | 3 | 67.5 | |||||
appendicular lean mass | 2 | 1 | 2 | 67.1 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 2 | 77.6 | |||||
mean platelet volume | 2 | 75.5 | |||||
0 | 1.1 | 68.5 | |||||
hemoglobin measurement | 3 | 67.5 | |||||
appendicular lean mass | 2 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494] | |||||||
Mouse | MGI:2137913 | 94352 | ||||||
Rat | RGD:1308435 | 290350 | ||||||
Dog | lysyl oxidase like 2 | VGNC:42739 | 486118 | |||||
Horse | lysyl oxidase like 2 | VGNC:19724 | 100058083 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494] | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysyl oxidase like 2 | |||||
Horse | lysyl oxidase like 2 | |||||
Publication Statistics
PubMed Score 216.53
PubMed score by year
PubTator Score 117.12
PubTator score by year
Related Publications
Text Mined References (100)
GeneRif Annotations (85)
Items per page:
0 of 0
PMID | Year | Title |
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