Protein Summary
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000269192
- ENSP00000269192
- ENSG00000134769
- ENST00000283365
- ENSP00000283365
- ENST00000315456
- ENSP00000322519
- ENST00000348997
- ENSP00000336682
- ENST00000399113
- ENSP00000382064
- ENST00000399121
- ENSP00000382072
- ENST00000444659
- ENSP00000405819
- ENST00000554864
- ENSP00000451516
- ENST00000556414
- ENSP00000452255
- ENST00000591182
- ENSP00000467720
- ENST00000595022
- ENSP00000473078
- ENST00000596745
- ENSP00000469121
- ENST00000597599
- ENSP00000473119
- ENST00000597674
- ENSP00000471783
- ENST00000598142
- ENSP00000470716
- ENST00000598334
- ENSP00000470152
- ENST00000598774
- ENSP00000472031
- DRP3
- DTN
- DRP3
- DTN-A
- LVNC1
- D18S892E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.96 | ||
microRNA | 0.92 | ||
transcription factor | 0.87 | ||
PubMedID | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.23 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.23 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0