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Tbio
MYO5A
Unconventional myosin-Va

Protein Summary
Description
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356338
  • ENSP00000348693
  • ENSG00000197535
  • ENST00000399231
  • ENSP00000382177

Symbol
  • MYH12
  • GS1
  • MYO5
  • MYH12
  • MYR12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
virus perturbation
0.98
biological process
0.97
hub protein
0.97
transcription factor perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.8   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.8   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
94.3
mean platelet volume
2
2
2
72.3
testosterone measurement
1
1
1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
94.3
mean platelet volume
2
72.3
testosterone measurement
1
58.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VA
VGNC:14644
450136
Macaque
myosin VA
574273
Mouse
MGI:105976
17918
Rat
RGD:3143
25017
Dog
myosin VA
VGNC:43568
478312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VA
Macaque
myosin VA
Mouse
Rat
Dog
myosin VA
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4I1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin processing
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Insulin processing
Membrane Trafficking
Gene Ontology Terms (52)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (213)
1 – 10 of 213
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.999940628
p_ni: 0.00005937
p_wrong: 2e-9
Score: 0.164
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.998169584
p_ni: 0.001830415
p_wrong: 1e-9
Score: 0.198
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.997079473
p_ni: 0.002920527
Score: 0.237
Data Source: BioPlex,STRINGDB
TMOD4
Tbio
Novelty: 0.00932697
p_int: 0.996901184
p_ni: 0.003098816
Score: 0.22
Data Source: BioPlex,STRINGDB
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.996847475
p_ni: 0.003152525
Score: 0.207
Data Source: BioPlex,STRINGDB
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.991601236
p_ni: 0.008398764
Score: 0.182
Data Source: BioPlex,STRINGDB
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.983508168
p_ni: 0.016491832
Data Source: BioPlex
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.981797496
p_ni: 0.018202504
Data Source: BioPlex
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.96360372
p_ni: 0.036396279
Score: 0.194
Data Source: BioPlex,STRINGDB
EID1
Tbio
Novelty: 0.02414732
p_int: 0.950230321
p_ni: 0.049769679
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  279.80

PubMed score by year
PubTator Score  339.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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