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Tbio
IRS2
Insulin receptor substrate 2

Protein Summary
Description
May mediate the control of various cellular processes by insulin. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375856
  • ENSP00000365016
  • ENSG00000185950

Symbol
  • IRS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
0.99
small molecule perturbation
0.98
gene perturbation
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.69   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.69   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
89.5
platelet count
4
4
5
89.3
reticulocyte count
3
4
4
88
mean corpuscular hemoglobin concentration
1
1
1
83.3
mean reticulocyte volume
1
1
1
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
89.5
platelet count
5
89.3
reticulocyte count
4
88
mean corpuscular hemoglobin concentration
1
83.3
mean reticulocyte volume
1
77.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin receptor substrate 2
VGNC:13119
452657
Macaque
insulin receptor substrate 2 [Source:HGNC Symbol;Acc:HGNC:6126]
Mouse
MGI:109334
384783
Rat
RGD:69316
29376
Dog
insulin receptor substrate 2
VGNC:42099
485548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin receptor substrate 2
Macaque
insulin receptor substrate 2 [Source:HGNC Symbol;Acc:HGNC:6126]
Mouse
Rat
Dog
insulin receptor substrate 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4H2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (121)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Gene Ontology Terms (42)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (210)
1 – 10 of 210
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
p_int:  1
Score:  0.972
Data Source:  BioPlex,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.994
Data Source:  Reactome,STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.993
Data Source:  Reactome,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.986
Data Source:  Reactome,STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.983
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.982
Data Source:  Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.98
Data Source:  Reactome,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.976
Data Source:  Reactome,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.974
Data Source:  Reactome,STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
Score:  0.973
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  565.69

PubMed score by year
PubTator Score  316.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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