Tbio IRS2 Insulin receptor substrate 2

Protein Summary

Description

May mediate the control of various cellular processes by insulin. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y4H2
• Q96RR2
• Q9BZG0
• Q9Y6I5
• IRS-2

Gene Name

• IRS2

Ensembl ID

• ENST00000375856
• ENSP00000365016
• ENSG00000185950

Symbol

• IRS-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
kinase	0.99
small molecule perturbation	0.98
gene perturbation	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 604.97   (req: < 5)

Gene RIFs: 159   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 604.97   (req: >= 5)

Gene RIFs: 159   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0