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Tbio
RAPGEF2
Rap guanine nucleotide exchange factor 2

Protein Summary
Description
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264431
  • ENSP00000264431
  • ENSG00000109756

Symbol
  • KIAA0313
  • NRAPGEP
  • PDZGEF1
  • RAGEF
  • RA-GEF
  • NRAPGEP
  • PDZGEF1
  • Rap-GEP
  • CNrasGEF
  • PDZ-GEF1
  • RA-GEF-1
  • nRap GEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.99
transcription factor perturbation
0.84
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
RAPGEF6
Tbio
Novelty:  0.07979293
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.809
Data Source:  BioPlex,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.994
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.968
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.944
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.943
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.942
Data Source:  STRINGDB
MAGI2
Tbio
Family:  Enzyme
Novelty:  0.01674725
Score:  0.938
Data Source:  STRINGDB
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
Score:  0.938
Data Source:  STRINGDB
MRAS
Tbio
Family:  Enzyme
Novelty:  0.01544981
Score:  0.937
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets (22)
Explore Nearest Tclin Targets
1 – 5 of 18
FLT4
Tclin
Family:  Kinase
KEGG Distance:  7
Common Pathways:  2
NGFR
Tclin
Family:  Other
KEGG Distance:  7
Common Pathways:  2
EGFR
Tclin
Family:  Kinase
KEGG Distance:  7
Common Pathways:  2
INSR
Tclin
Family:  Kinase
KEGG Distance:  7
Common Pathways:  2
KIT
Tclin
Family:  Kinase
KEGG Distance:  7
Common Pathways:  2
Pathways (14)
Cytokine Signaling in Immune system (R-HSA-1280215)

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1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (62)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 2
VGNC:670
461577
Macaque
Rap guanine nucleotide exchange factor 2
704717
Mouse
MGI:2659071
76089
Rat
RGD:1306434
310533
Dog
Rap guanine nucleotide exchange factor 2
VGNC:45347
100856359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 2
Macaque
Rap guanine nucleotide exchange factor 2
Mouse
Rat
Dog
Rap guanine nucleotide exchange factor 2
Publication Statistics
PubMed Score 35.03
PubMed score by year
PubTator Score 17.79
PubTator score by year
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Related Publications
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PMID
Year
Title