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Tbio
TLN2
Talin-2

Protein Summary
Description
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000561311
  • ENSP00000453508
  • ENSG00000171914

Symbol
  • KIAA0320
  • ILWEQ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.97
co-expressed gene
0.65
disease perturbation
0.62
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.43   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.43   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
6
8
97.6
reticulocyte count
7
10
15
95.9
heel bone mineral density
2
2
3
57.1
myeloid white cell count
1
1
1
54.4
leukocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
8
97.6
reticulocyte count
15
95.9
heel bone mineral density
3
57.1
myeloid white cell count
1
54.4
leukocyte count
1
44.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
talin 2
705008
Mouse
MGI:1917799
70549
Rat
RGD:1565416
315776
Dog
talin 2
VGNC:47402
478331
Horse
talin 2
VGNC:24136
100054133
Species
Name
OMA
EggNOG
Inparanoid
Macaque
talin 2
Mouse
Rat
Dog
talin 2
Horse
talin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4G6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (97)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Platelet activation
KEGG
Focal adhesion
KEGG
Human T-cell leukemia virus 1 infection
KEGG
Rap1 signaling pathway
Name
Explore in Pharos
Explore in Source
Platelet activation
Focal adhesion
Human T-cell leukemia virus 1 infection
Rap1 signaling pathway
Protein-Protein Interactions (97)
1 – 10 of 97
KANK4
Tdark
Novelty:  0.22871735
p_int:  0.999999873
p_ni:  1.26e-7
p_wrong:  2e-9
Score:  0.361
Data Source:  BioPlex,STRINGDB
RGCC
Tbio
Novelty:  0.02696671
p_int:  0.999999811
p_ni:  1.82e-7
p_wrong:  7e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.999999777
p_ni:  2.23e-7
Data Source:  BioPlex
VCL
Tbio
Novelty:  0.00043107
Score:  0.991
Data Source:  STRINGDB
APBB1IP
Tbio
Novelty:  0.01684051
Score:  0.978
Data Source:  STRINGDB
PIP5K1C
Tchem
Family:  Kinase
Novelty:  0.0323077
Score:  0.963
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.953
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.951
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.945
Data Source:  STRINGDB
DDI2
Tbio
Novelty:  0.09288646
Score:  0.885
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.43

PubMed score by year
PubTator Score  19.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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