Tbio MARF1 Meiosis regulator and mRNA stability factor 1

Protein Summary

Description

Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9Y4F3
• A8MSK2
• B2RNX2
• B4DYY9
• B7ZMG1
• B7ZMG2
• F8VV09
• Q6P1R6
• Q8WYR2
• Q9Y4J9

Gene Name

• MARF1

Ensembl ID

• ENST00000396368
• ENSP00000379654
• ENSG00000166783
• ENST00000548025
• ENSP00000449376
• ENST00000551742
• ENSP00000450309
• ENST00000621511
• ENSP00000479383
• ENSG00000277140
• ENST00000632465
• ENSP00000487685
• ENST00000632628
• ENSP00000488025

Symbol

• KIAA0430
• LKAP
• LKAP
• LMKB
• PPP1R34
• KIAA0430

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Meiosis Regulator And Mrna Stability Factor 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Meiosis Regulator And Mrna Stability Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0