You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZNF451
E3 SUMO-protein ligase ZNF451

Protein Summary
Description
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357489
  • ENSP00000350083
  • ENSG00000112200
  • ENST00000370706
  • ENSP00000359740
  • ENST00000370708
  • ENSP00000359742

Symbol
  • COASTER
  • KIAA0576
  • KIAA1702
  • COASTER
  • dJ417I1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.84
kinase perturbation
0.84
transcription factor binding site profile
0.84
cell type or tissue
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.999998032
p_ni:  0.000001342
p_wrong:  6.26e-7
Score:  0.348
Data Source:  BioPlex,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.983
Data Source:  STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
Score:  0.844
Data Source:  STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.841
Data Source:  STRINGDB
SUMO4
Tbio
Novelty:  0.01534859
Score:  0.783
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.761
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.682
Data Source:  STRINGDB
PDE7A
Tclin
Family:  Enzyme
Novelty:  0.00872596
Score:  0.672
Data Source:  STRINGDB
P42167
Tbio
Novelty:  0.00715046
Score:  0.671
Data Source:  STRINGDB
P42166
Tbio
Novelty:  0.00715046
Score:  0.671
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein sumoylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein sumoylation.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
10.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
10.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 451
VGNC:7948
462796
Macaque
zinc finger protein 451
715305
Mouse
MGI:2137896
98403
Rat
RGD:1305865
316312
Dog
zinc finger protein 451
VGNC:48732
474949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 451
Macaque
zinc finger protein 451
Mouse
Rat
Dog
zinc finger protein 451
Publication Statistics
PubMed Score 7.95
PubMed score by year
PubTator Score 4.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title