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Tbio
WASHC2C
WASH complex subunit 2C

Protein Summary
Description
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374362
  • ENSP00000363482
  • ENSG00000172661
  • ENST00000537517
  • ENSP00000442128
  • ENST00000540872
  • ENSP00000439811

Symbol
  • FAM21C
  • KIAA0592
  • VPEF
  • FAM21A
  • FAM21C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.22   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.22   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
82.9
mean corpuscular hemoglobin concentration
1
1
1
82.7
red blood cell distribution width
1
1
1
82.1
alkaline phosphatase measurement
1
1
1
73
reticulocyte measurement
1
1
1
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
82.9
mean corpuscular hemoglobin concentration
1
82.7
red blood cell distribution width
1
82.1
alkaline phosphatase measurement
1
73
reticulocyte measurement
1
67.8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4E1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (35)
1 – 10 of 35
WASHC1
Tbio
Novelty:  0.09242196
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999993
p_ni:  2e-9
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999999986
p_ni:  1e-9
p_wrong:  1.3e-8
Score:  0.787
Data Source:  BioPlex,STRINGDB
WASHC4
Tdark
Novelty:  0.05930527
Score:  0.999
Data Source:  STRINGDB
WASHC5
Tbio
Novelty:  0.02909884
Score:  0.988
Data Source:  STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
Score:  0.942
Data Source:  STRINGDB
CAPZA1
Tbio
Novelty:  0.03448517
Score:  0.941
Data Source:  STRINGDB
WASHC2A
Tdark
Novelty:  1.4430096
Score:  0.831
Data Source:  STRINGDB
ZFAND4
Tdark
Novelty:  0.22188427
Score:  0.8
Data Source:  STRINGDB
VPS35
Tbio
Novelty:  0.00729892
Score:  0.796
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.22

PubMed score by year
PubTator Score  6.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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