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Tbio
PLXND1
Plexin-D1

Protein Summary
Description
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324093
  • ENSP00000317128
  • ENSG00000004399

Symbol
  • KIAA0620
  • PLEXD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.94
disease perturbation
0.83
PubMedID
0.8
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.89   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.89   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
21
39
98.8
waist-hip ratio
4
17
18
98.8
BMI-adjusted hip circumference
3
19
22
98.6
hip circumference
3
18
21
98
waist circumference
1
10
10
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
39
98.8
waist-hip ratio
18
98.8
BMI-adjusted hip circumference
22
98.6
hip circumference
21
98
waist circumference
10
92.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2154244
67784
Rat
RGD:1310796
312652
Dog
plexin D1
VGNC:44726
476526
Horse
plexin D1
VGNC:21607
100056548
Cow
plexin D1
VGNC:33065
781625
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
plexin D1
Horse
plexin D1
Cow
plexin D1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4D7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NOTCH3 Intracellular Domain Regulates Transcription
Other semaphorin interactions
Semaphorin interactions
Gene Ontology Terms (26)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (93)
1 – 10 of 93
SEMA3E
Tbio
Novelty:  0.00936004
Score:  0.995
Data Source:  Reactome,STRINGDB
SEMA4A
Tbio
Novelty:  0.01062916
Score:  0.994
Data Source:  Reactome,STRINGDB
SEMA3C
Tbio
Novelty:  0.00828813
Score:  0.992
Data Source:  STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.98
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.959
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.954
Data Source:  STRINGDB
RND2
Tbio
Family:  Enzyme
Novelty:  0.01278315
Score:  0.941
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.94
Data Source:  STRINGDB
SEMA3F
Tbio
Novelty:  0.00676786
Score:  0.92
Data Source:  STRINGDB
SEMA5B
Tbio
Novelty:  0.0151789
Score:  0.919
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.89

PubMed score by year
PubTator Score  31.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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