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Tchem
DAGLA
Sn1-specific diacylglycerol lipase alpha

Protein Summary
Description
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257215
  • ENSP00000257215
  • ENSG00000134780

Symbol
  • C11orf11
  • KIAA0659
  • NSDDR
  • NSDDR
  • C11orf11
  • DAGLALPHA
  • DAGL(ALPHA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.82
cell line
0.68
small molecule perturbation
0.64
transcription factor binding site profile
0.64
cell type or tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
89.1
refractive error measurement
1
1
1
79.8
C-reactive protein measurement
1
1
1
78.3
wellbeing measurement
3
1
3
67.2
neuroticism measurement
1
1
1
60.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
89.1
refractive error measurement
1
79.8
C-reactive protein measurement
1
78.3
wellbeing measurement
3
67.2
neuroticism measurement
1
60.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol lipase alpha
VGNC:11335
451241
Mouse
MGI:2677061
269060
Rat
RGD:1359461
309207
Dog
diacylglycerol lipase alpha
VGNC:39764
483795
Horse
diacylglycerol lipase alpha
VGNC:17001
100059772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol lipase alpha
Mouse
Rat
Dog
diacylglycerol lipase alpha
Horse
diacylglycerol lipase alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4D2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (133)
Arachidonate production from DAG (R-HSA-426048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonate production from DAG
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Arachidonate production from DAG
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (17)
1 – 10 of 17
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.999998893
p_ni: 6.52e-7
p_wrong: 4.56e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.999638721
p_ni: 0.00000454
p_wrong: 0.000356739
Score: 0.188
Data Source: BioPlex,STRINGDB
DAGLB
Tchem
Family: Enzyme
Novelty: 0.03269024
Score: 0.831
Data Source: STRINGDB
NAPEPLD
Tbio
Family: Enzyme
Novelty: 0.00755191
Score: 0.811
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.794
Data Source: STRINGDB
ABHD6
Tchem
Family: Enzyme
Novelty: 0.019314
Score: 0.756
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.734
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.718
Data Source: STRINGDB
ABHD12
Tchem
Family: Enzyme
Novelty: 0.02587535
Score: 0.709
Data Source: STRINGDB
FAAH2
Tchem
Family: Enzyme
Novelty: 0.06197067
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.71

PubMed score by year
PubTator Score  24.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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