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Tchem
KDM3A
Lysine-specific demethylase 3A

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312912
  • ENSP00000323659
  • ENSG00000115548
  • ENST00000409064
  • ENSP00000386516
  • ENST00000409556
  • ENSP00000386660

Symbol
  • JHDM2A
  • JMJD1
  • JMJD1A
  • KIAA0742
  • TSGA
  • TSGA
  • JMJD1
  • JHDM2A
  • JHMD2A
  • JMJD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor binding site profile
0.95
molecular function
0.9
biological process
0.89
transcription factor
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.12   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.12   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
78.2
unipolar depression
1
1
0
1
56.8
neuroticism measurement
2
2
1
5.8
40.4
depressive symptom measurement
1
1
1
24.5
worry measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.2
unipolar depression
0
1
56.8
neuroticism measurement
1
5.8
40.4
depressive symptom measurement
1
24.5
worry measurement
1
21.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 3A
VGNC:275
470424
Macaque
lysine demethylase 3A
697775
Mouse
MGI:98847
104263
Rat
RGD:708351
312440
Dog
lysine demethylase 3A
VGNC:42322
475763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 3A
Macaque
lysine demethylase 3A
Mouse
Rat
Dog
lysine demethylase 3A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y4C1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (38)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (101)
1 – 10 of 101
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  1
Score:  0.186
Data Source:  BioPlex,STRINGDB
RASSF6
Tbio
Novelty:  0.04940382
p_int:  0.999997134
p_ni:  0.000002741
p_wrong:  1.25e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.881
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.877
Data Source:  STRINGDB
GART
Tclin
Novelty:  0.00524985
Score:  0.822
Data Source:  STRINGDB
KDM3B
Tbio
Family:  Epigenetic
Novelty:  0.05322289
Score:  0.821
Data Source:  STRINGDB
EIF4H
Tchem
Novelty:  0.03604365
Score:  0.817
Data Source:  STRINGDB
KDM4C
Tchem
Family:  Epigenetic
Novelty:  0.01347559
Score:  0.808
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.804
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  129.12

PubMed score by year
PubTator Score  56.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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