Protein Summary
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
- ENST00000554719
- ENSP00000451648
- ENSG00000021645
- ENST00000554738
- ENSP00000450683
- C14orf60
- KIAA0743
- C14orf60
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.49 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 223 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.49 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 223 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (172)
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neurexins and neuroligins | ||||
Reactome | Neuronal System | ||||
Reactome | Protein-protein interactions at synapses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neurexins and neuroligins | ||||
Neuronal System | ||||
Protein-protein interactions at synapses | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 12 | 4 | 44 | 96 | |||||
body mass index | 12 | 4 | 44 | 96 | |||||
5 | 5 | 6 | 1.1 | 93.6 | |||||
5 | 5 | 6 | 1.1 | 93.6 | |||||
anthropometric measurement | 1 | 2 | 0 | 1.1 | 81 | ||||
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 44 | 96 | |||||
body mass index | 44 | 96 | |||||
6 | 1.1 | 93.6 | |||||
6 | 1.1 | 93.6 | |||||
anthropometric measurement | 0 | 1.1 | 81 | ||||
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IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | neurexin 3 | 678699 | ||||||
Mouse | MGI:1096389 | 18191 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | neurexin 3 | |||||
Mouse | ||||||
Publication Statistics
PubMed Score 137.49
PubMed score by year
PubTator Score 36.81
PubTator score by year
Related Publications
Text Mined References (55)
GeneRif Annotations (28)
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0 of 0
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