Tbio MTCL1 Microtubule cross-linking factor 1

Protein Summary

Description

Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.

Uniprot Accession IDs

• Q9Y4B5
• E9PAY7
• Q6ZMQ9
• Q8IWA9

Gene Name

• MTCL1

Ensembl ID

• ENST00000306329
• ENSP00000305027
• ENSG00000168502
• ENST00000359865
• ENSP00000352927
• ENST00000400050
• ENSP00000382924
• ENST00000517570
• ENSP00000429556
• ENST00000518815
• ENSP00000463465

Symbol

• CCDC165
• KIAA0802
• SOGA2
• SOGA2
• CCDC165
• KIAA0802

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
protein complex	0.72
gene perturbation	0.7
PubMedID	0.69
small molecule perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0