Tbio RAD54L2 Helicase ARIP4

Protein Summary

Description

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

Uniprot Accession IDs

• Q9Y4B4
• Q8TB57
• Q9BV54

Gene Name

• RAD54L2

Ensembl ID

• ENST00000409535
• ENSP00000386520
• ENSG00000164080

Symbol

• ARIP4
• KIAA0809
• ARIP4
• HSPC325
• SRISNF2L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule perturbation	0.64
cell line	0.62
tissue sample	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0