Tdark RAD54L2 Helicase ARIP4

Protein Summary

Description

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

Uniprot Accession IDs

• Q9Y4B4
• Q8TB57
• Q9BV54

Gene Name

• RAD54L2

Ensembl ID

• ENST00000409535
• ENSP00000386520
• ENSG00000164080

Symbol

• ARIP4
• KIAA0809
• ARIP4
• HSPC325
• SRISNF2L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule perturbation	0.64
cell line	0.62
tissue sample	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

PIAS4

Tbio

Family:  TF

Novelty:  0.01388547

p_int:  0.999997739

p_ni:  0.000002244

p_wrong:  1.7e-8

Score:  0.196

Data Source:  BioPlex,STRINGDB

DYRK1B

Tchem

Family:  Kinase

Novelty:  0.01960932

p_int:  0.999997502

p_ni:  0.000002496

p_wrong:  2e-9

Score:  0.193

Data Source:  BioPlex,STRINGDB

DCAF7

Tbio

Novelty:  0.02609518

p_int:  0.999971984

p_ni:  0.000027884

p_wrong:  1.32e-7

Score:  0.52

Data Source:  BioPlex,STRINGDB

ADPRHL2

Tbio

Family:  Enzyme

Novelty:  0.02261777

p_int:  0.998325612

p_ni:  0.001674388

p_wrong:  1e-9

Data Source:  BioPlex

DYRK1A

Tchem

Family:  Kinase

Novelty:  0.00226963

p_int:  0.997312181

p_ni:  0.002687796

p_wrong:  2.3e-8

Score:  0.607

Data Source:  BioPlex,STRINGDB

PCDHAC2

Tdark

Novelty:  0.28397695

p_int:  0.760256327

p_ni:  0.000076634

p_wrong:  0.239667039

Score:  0.218

Data Source:  BioPlex,STRINGDB

AR

Tclin

Family:  NR

Novelty:  0.00013531

Score:  0.767

Data Source:  STRINGDB

BRCA1

Tchem

Novelty:  0.00011146

Score:  0.729

Data Source:  STRINGDB

ERC2

Tbio

Novelty:  0.00953771

Score:  0.659

Data Source:  STRINGDB

CACNA2D3

Tbio

Family:  IC

Novelty:  0.05267262

Score:  0.608

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	AndrogenReceptor	164 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
AndrogenReceptor	164 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
helicase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergic rhinitis	EFO_0005854	1	1	0	1.1	58.4
mathematical ability	EFO_0004875	1	1	1		46.1
testosterone measurement	EFO_0004908	1	1	1		42.3
macrophage inflammatory protein 1b measurement	EFO_0008219	1	2	2		40.4
self reported educational attainment	EFO_0004784	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergic rhinitis	EFO_0005854	0	1.1	58.4
mathematical ability	EFO_0004875	1		46.1
testosterone measurement	EFO_0004908	1		42.3
macrophage inflammatory protein 1b measurement	EFO_0008219	2		40.4
self reported educational attainment	EFO_0004784	1		35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
ATP-binding
Complete proteome
DNA-binding
Helicase
Hydrolase
Isopeptide bond
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
macrophage inflammatory protein 1b measurement
mathematical ability
self reported educational attainment
testosterone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RAD54 like 2		745605
Macaque	RAD54 like 2 [Source:HGNC Symbol;Acc:HGNC:29123]
Mouse	RAD54 like 2 (S. cerevisiae)	MGI:1933196	81000
Rat	RAD54 like 2	RGD:1561889	363135
Dog	RAD54 like 2	VGNC:49612	476608

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RAD54 like 2
Macaque	RAD54 like 2 [Source:HGNC Symbol;Acc:HGNC:29123]
Mouse	RAD54 like 2 (S. cerevisiae)
Rat	RAD54 like 2
Dog	RAD54 like 2

Publication Statistics

PubMed Score 4.89

PubMed score by year

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PubTator Score 4.15

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title