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Tbio
TRRAP
Transformation/transcription domain-associated protein

Protein Summary
Description
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355540
  • ENSP00000347733
  • ENSG00000196367
  • ENST00000359863
  • ENSP00000352925

Symbol
  • PAF400
  • Tra1
  • TR-AP
  • PAF400
  • STAF40
  • PAF350/400
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
protein domain
0.97
drug perturbation
0.96
cellular component
0.91
protein complex
0.91


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GENEVA
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
4
4
62.3
mean corpuscular volume
1
2
2
52.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
4
62.3
mean corpuscular volume
2
52.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transformation/transcription domain associated protein
VGNC:8785
463564
Macaque
transformation/transcription domain associated protein
707047
Mouse
MGI:2153272
100683
Dog
transformation/transcription domain associated protein
VGNC:47887
479747
Horse
transformation/transcription domain associated protein
VGNC:51257
100059214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transformation/transcription domain associated protein
Macaque
transformation/transcription domain associated protein
Mouse
Dog
transformation/transcription domain associated protein
Horse
transformation/transcription domain associated protein
Protein Structure (0 Structures, 14 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
Formation of the beta-catenin:TCF transactivating complex
HATs acetylate histones
Protein-Protein Interactions (328)
1 – 10 of 328
FOXR2
Tbio
Family: TF
Novelty: 0.06548862
p_int: 0.999997068
p_ni: 0.000002932
Score: 0.779
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.999996668
p_ni: 0.000003332
Score: 0.752
Data Source: BioPlex,STRINGDB
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999995992
p_ni: 0.000004008
Score: 0.992
Data Source: BioPlex,STRINGDB
PLAC1
Tbio
Novelty: 0.01213036
p_int: 0.999987102
p_ni: 0.000012898
Score: 0.803
Data Source: BioPlex,STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
p_int: 0.999980271
p_ni: 0.000019729
Score: 0.995
Data Source: BioPlex,STRINGDB
EPC2
Tbio
Novelty: 0.02760809
p_int: 0.999968567
p_ni: 0.000031434
Score: 0.96
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999968259
p_ni: 0.000031741
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
FOXR1
Tbio
Family: TF
Novelty: 0.20300395
p_int: 0.999964764
p_ni: 0.000035236
Score: 0.741
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999963808
p_ni: 0.000036192
Score: 0.929
Data Source: BioPlex,STRINGDB
MRGBP
Tbio
Novelty: 0.09537142
p_int: 0.999953057
p_ni: 0.000046943
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.63

PubMed score by year
PubTator Score  66.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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