You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIF3A
Kinesin-like protein KIF3A

Protein Summary
Description
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378746
  • ENSP00000368020
  • ENSG00000131437

Symbol
  • KIF3
  • FLA10
  • KLP-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
microRNA
0.81
kinase perturbation
0.76
cell line
0.65
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.82   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.82   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0