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Tbio
ZAN
Zonadhesin

Protein Summary
Description
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000538115
  • ENSP00000445091
  • ENSG00000146839
  • ENST00000542585
  • ENSP00000444427
  • ENST00000546213
  • ENSP00000441117
  • ENST00000546292
  • ENSP00000445943
  • ENST00000613979
  • ENSP00000480750
  • ENST00000618565
  • ENSP00000478371
  • ENST00000620596
  • ENSP00000481742
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.81
cell line
0.57
tissue sample
0.49
cellular component
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
1
1
1
49.2
mean corpuscular hemoglobin concentration
1
1
1
49.2
white matter hyperintensity measurement
1
1
0
5.6
22
heel bone mineral density
1
1
1
18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
1
49.2
mean corpuscular hemoglobin concentration
1
49.2
white matter hyperintensity measurement
0
5.6
22
heel bone mineral density
1
18
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
TECTB
Tbio
Novelty: 0.04489491
Score: 0.8
Data Source: STRINGDB
ZP3
Tbio
Novelty: 0.00140352
Score: 0.8
Data Source: STRINGDB
NID1
Tbio
Novelty: 0.00169075
Score: 0.715
Data Source: STRINGDB
AFG1L
Tbio
Novelty: 0.0034716
Score: 0.71
Data Source: STRINGDB
SPESP1
Tbio
Novelty: 0.00308451
Score: 0.677
Data Source: STRINGDB
SPATA5
Tbio
Family: Enzyme
Novelty: 0.00416454
Score: 0.644
Data Source: STRINGDB
ACR
Tchem
Family: Enzyme
Novelty: 0.00068607
Score: 0.634
Data Source: STRINGDB
ZPBP
Tbio
Novelty: 0.02857503
Score: 0.62
Data Source: STRINGDB
SNRPC
Tbio
Novelty: 0.02049921
Score: 0.596
Data Source: STRINGDB
C7orf43
Tdark
Novelty: 1.11975505
Score: 0.596
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.90

PubMed score by year
PubTator Score  27.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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