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Tbio
TLN1
Talin-1

Protein Summary
Description
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314888
  • ENSP00000316029
  • ENSG00000137076

Symbol
  • KIAA1027
  • TLN
  • TLN
  • ILWEQ
  • talin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
transcription factor perturbation
0.98
disease perturbation
0.97
transcription factor binding site profile
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.93   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.93   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
77.4
lymphocyte count
2
1
2
75.7
heel bone mineral density
1
1
1
63.8
platelet crit
1
1
1
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
77.4
lymphocyte count
2
75.7
heel bone mineral density
1
63.8
platelet crit
1
30.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
talin 1
VGNC:13977
465082
Macaque
talin 1
696298
Mouse
MGI:1099832
21894
Rat
RGD:1306247
313494
Dog
talin 1
VGNC:47401
100856393
Species
Name
OMA
EggNOG
Inparanoid
Chimp
talin 1
Macaque
talin 1
Mouse
Rat
Dog
talin 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y490-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (74)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (231)
1 – 10 of 231
KANK4
Tdark
Novelty: 0.22871735
p_int: 0.999942121
p_ni: 0.000057879
Score: 0.215
Data Source: BioPlex,STRINGDB
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.998046048
p_ni: 0.001953952
Data Source: BioPlex
RGCC
Tbio
Novelty: 0.02696671
p_int: 0.992598098
p_ni: 0.007401902
Score: 0.534
Data Source: BioPlex,STRINGDB
BLVRA
Tbio
Family: Enzyme
Novelty: 0.00526407
p_int: 0.967641596
p_ni: 0.032358404
Score: 0.222
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.939241696
p_ni: 0.060758304
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.876798763
p_ni: 0.123201237
Score: 0.932
Data Source: BioPlex,Reactome,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.86408543
p_ni: 0.13591457
Data Source: BioPlex
VCL
Tbio
Novelty: 0.00043107
Score: 0.999
Data Source: Reactome,STRINGDB
PIP5K1C
Tchem
Family: Kinase
Novelty: 0.0323077
Score: 0.996
Data Source: Reactome,STRINGDB
APBB1IP
Tbio
Novelty: 0.01684051
Score: 0.993
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  144.93

PubMed score by year
PubTator Score  72.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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