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Tbio
ATP6V0A2
V-type proton ATPase 116 kDa subunit a isoform 2

Protein Summary
Description
Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330342
  • ENSP00000332247
  • ENSG00000185344

Symbol
  • A2
  • RTF
  • TJ6
  • WSS
  • ARCL
  • J6B7
  • STV1
  • TJ6M
  • TJ6S
  • VPH1
  • ARCL2A
  • ATP6A2
  • ATP6N1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.96
kinase perturbation
0.95
virus perturbation
0.95
biological process
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.51   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.51   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
1
1
1
53.4
neutrophil count
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
1
53.4
neutrophil count
1
7.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a2
VGNC:8344
452354
Macaque
ATPase H+ transporting V0 subunit a2
710162
Mouse
MGI:104855
21871
Dog
ATPase H+ transporting V0 subunit a2
VGNC:38269
486245
Horse
ATPase H+ transporting V0 subunit a2
VGNC:15668
100061140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a2
Macaque
ATPase H+ transporting V0 subunit a2
Mouse
Dog
ATPase H+ transporting V0 subunit a2
Horse
ATPase H+ transporting V0 subunit a2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y487-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (163)
1 – 10 of 163
TMEM199
Tbio
Novelty: 0.05799147
p_int: 0.999999997
p_ni: 3e-9
Score: 0.958
Data Source: BioPlex,STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999999991
p_ni: 9e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
p_int: 0.999999968
p_ni: 3.2e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
KIAA2013
Tdark
Novelty: 0.4705158
p_int: 0.999999903
p_ni: 9.7e-8
Score: 0.844
Data Source: BioPlex,STRINGDB
TMCC3
Tdark
Novelty: 0.67741343
p_int: 0.999999109
p_ni: 8.91e-7
Score: 0.184
Data Source: BioPlex,STRINGDB
CLCN6
Tchem
Family: IC
Novelty: 0.02775193
p_int: 0.99999199
p_ni: 0.000001044
p_wrong: 0.000006966
Score: 0.538
Data Source: BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
p_int: 0.999988373
p_ni: 0.000011627
Score: 0.928
Data Source: BioPlex,STRINGDB
SPRYD7
Tdark
Novelty: 0.25334319
p_int: 0.999988248
p_ni: 0.000011746
p_wrong: 6e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
CCDC115
Tbio
Novelty: 0.23966137
p_int: 0.999940176
p_ni: 0.000059565
p_wrong: 2.59e-7
Score: 0.916
Data Source: BioPlex,STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
p_int: 0.999890016
p_ni: 0.000109984
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  205.51

PubMed score by year
PubTator Score  780.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer